IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS

Abstract. The study included patients with chronic uveitis caused by herpes simplex virus (HSV), or mixed HSV/ cytomegalovirus (CMV) infections. Deficiencies in CD3+ and CD4+ T lymphocytes and significant increase of CD8+ lymphocyte subpopulations were found in posterior uveitis. A single-pathogen (...

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Autores principales:	M. D. Guliamova, A. P. Rizopulu, H. M. Kamilov, U. S. Faisieva, A. A. Umarova, F. Yu. Garib, T. U. Aripova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	uveitis cytomegalovirus herpes simplex virus cytokines lymphocytes activation markers Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a1a899be32b24759bd16f0b0db1d83db
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spelling	oai:doaj.org-article:a1a899be32b24759bd16f0b0db1d83db2021-11-18T08:03:43ZIMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS1563-06252313-741X10.15789/1563-0625-2005-5-6-543-550https://doaj.org/article/a1a899be32b24759bd16f0b0db1d83db2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/621https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The study included patients with chronic uveitis caused by herpes simplex virus (HSV), or mixed HSV/ cytomegalovirus (CMV) infections. Deficiencies in CD3+ and CD4+ T lymphocytes and significant increase of CD8+ lymphocyte subpopulations were found in posterior uveitis. A single-pathogen (HSV) infection was characterized by decreased expression of CD3+ and CD4+ lymphocytes, IgG hypoglobulinaemia. Irrespectively of etiology, both groups of the patients exhibited sharp increase in CD16+ cells, as well as suppressed CD25+ receptors for IL-2, increased numbers of activated CD38+ lymphocytes, enhanced expression of late activation markers (CD95+ and HLA-DR+) in both mixed and single-pathogen uveitis. IFN-alpha is detected at low concentrations, or is absent; increased TNF-alpha production was noted in the tears in cases of posterior uveitis.Statistically significant interrelations have been found between expression of HLA-DR+, and CD3+; CD95+ and HLA-DR+; CD95+ lymphocytes and TNFalpha levels in the course of chronic persistence of Herpesviridae in the patients with chronic uveitis. The degree of immunological disturbances correlated with severity of clinical features.M. D. GuliamovaA. P. RizopuluH. M. KamilovU. S. FaisievaA. A. UmarovaF. Yu. GaribT. U. AripovaSPb RAACIarticleuveitiscytomegalovirusherpes simplex viruscytokineslymphocytes activation markersImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 5-6, Pp 543-550 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	uveitis cytomegalovirus herpes simplex virus cytokines lymphocytes activation markers Immunologic diseases. Allergy RC581-607
spellingShingle	uveitis cytomegalovirus herpes simplex virus cytokines lymphocytes activation markers Immunologic diseases. Allergy RC581-607 M. D. Guliamova A. P. Rizopulu H. M. Kamilov U. S. Faisieva A. A. Umarova F. Yu. Garib T. U. Aripova IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS
description	Abstract. The study included patients with chronic uveitis caused by herpes simplex virus (HSV), or mixed HSV/ cytomegalovirus (CMV) infections. Deficiencies in CD3+ and CD4+ T lymphocytes and significant increase of CD8+ lymphocyte subpopulations were found in posterior uveitis. A single-pathogen (HSV) infection was characterized by decreased expression of CD3+ and CD4+ lymphocytes, IgG hypoglobulinaemia. Irrespectively of etiology, both groups of the patients exhibited sharp increase in CD16+ cells, as well as suppressed CD25+ receptors for IL-2, increased numbers of activated CD38+ lymphocytes, enhanced expression of late activation markers (CD95+ and HLA-DR+) in both mixed and single-pathogen uveitis. IFN-alpha is detected at low concentrations, or is absent; increased TNF-alpha production was noted in the tears in cases of posterior uveitis.Statistically significant interrelations have been found between expression of HLA-DR+, and CD3+; CD95+ and HLA-DR+; CD95+ lymphocytes and TNFalpha levels in the course of chronic persistence of Herpesviridae in the patients with chronic uveitis. The degree of immunological disturbances correlated with severity of clinical features.
format	article
author	M. D. Guliamova A. P. Rizopulu H. M. Kamilov U. S. Faisieva A. A. Umarova F. Yu. Garib T. U. Aripova
author_facet	M. D. Guliamova A. P. Rizopulu H. M. Kamilov U. S. Faisieva A. A. Umarova F. Yu. Garib T. U. Aripova
author_sort	M. D. Guliamova
title	IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS
title_short	IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS
title_full	IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS
title_fullStr	IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS
title_full_unstemmed	IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS
title_sort	immunological characterization of the patients with chronic uveitis caused by herpes and cytomegalovirus
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/a1a899be32b24759bd16f0b0db1d83db
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IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS

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