Cerebral venous sinus thrombosis in patients with inflammatory bowel disease: a retrospective study

Abstract Cerebral venous sinus thrombosis (CVST) is a rare and devastating complication of inflammatory bowel disease (IBD). Early diagnosis and prompt treatment could improve prognosis. The aim of our study was to investigate the clinical data and predictive factors of inflammatory bowel disease in...

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Autores principales:	Wang Shujun, Zhang Huijie, Bai Xia, Wang Hongjian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a1a9a026ba5d4ca6864f35ed84ebf8df
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spelling	oai:doaj.org-article:a1a9a026ba5d4ca6864f35ed84ebf8df2021-12-02T16:45:54ZCerebral venous sinus thrombosis in patients with inflammatory bowel disease: a retrospective study10.1038/s41598-021-96541-y2045-2322https://doaj.org/article/a1a9a026ba5d4ca6864f35ed84ebf8df2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96541-yhttps://doaj.org/toc/2045-2322Abstract Cerebral venous sinus thrombosis (CVST) is a rare and devastating complication of inflammatory bowel disease (IBD). Early diagnosis and prompt treatment could improve prognosis. The aim of our study was to investigate the clinical data and predictive factors of inflammatory bowel disease in patients with a diagnosis of CVST. All IBD patient data were collected from July 2013 and September 2020. Clinical data, predictive factors and prognosis were compared between IBD patients with CVST and the IBD control group. The incidence of CVST in our study was 0.48%. The mean age of IBD patients with CVST was 34.9 years. The average duration of IBD was 4 years when cerebrovascular events occurred. The clinical presentation of CVST included headache (73.1%), vomiting (30.8%), limb dysmetria (26.9%), speech impairment (11.5%), blurred vision (7.7%), epileptic seizures (7.7%) and drowsiness (3.8%). The most common location for CVST was the transverse sinus (61.5%) followed by the superior sagittal sinus (30.8%). Anaemia, low albumin and elevated d-dimer were independent predictors of CVST in patients with IBD. Anticoagulation therapy was effective. The prognosis of IBD patients with CVST was worse than that of IBD patients without CVST. Early identification of the risk and clinical features of CVST in IBD patients is important. Prompt antithrombotic therapy is a safe and effective treatment.Wang ShujunZhang HuijieBai XiaWang HongjianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wang Shujun Zhang Huijie Bai Xia Wang Hongjian Cerebral venous sinus thrombosis in patients with inflammatory bowel disease: a retrospective study
description	Abstract Cerebral venous sinus thrombosis (CVST) is a rare and devastating complication of inflammatory bowel disease (IBD). Early diagnosis and prompt treatment could improve prognosis. The aim of our study was to investigate the clinical data and predictive factors of inflammatory bowel disease in patients with a diagnosis of CVST. All IBD patient data were collected from July 2013 and September 2020. Clinical data, predictive factors and prognosis were compared between IBD patients with CVST and the IBD control group. The incidence of CVST in our study was 0.48%. The mean age of IBD patients with CVST was 34.9 years. The average duration of IBD was 4 years when cerebrovascular events occurred. The clinical presentation of CVST included headache (73.1%), vomiting (30.8%), limb dysmetria (26.9%), speech impairment (11.5%), blurred vision (7.7%), epileptic seizures (7.7%) and drowsiness (3.8%). The most common location for CVST was the transverse sinus (61.5%) followed by the superior sagittal sinus (30.8%). Anaemia, low albumin and elevated d-dimer were independent predictors of CVST in patients with IBD. Anticoagulation therapy was effective. The prognosis of IBD patients with CVST was worse than that of IBD patients without CVST. Early identification of the risk and clinical features of CVST in IBD patients is important. Prompt antithrombotic therapy is a safe and effective treatment.
format	article
author	Wang Shujun Zhang Huijie Bai Xia Wang Hongjian
author_facet	Wang Shujun Zhang Huijie Bai Xia Wang Hongjian
author_sort	Wang Shujun
title	Cerebral venous sinus thrombosis in patients with inflammatory bowel disease: a retrospective study
title_short	Cerebral venous sinus thrombosis in patients with inflammatory bowel disease: a retrospective study
title_full	Cerebral venous sinus thrombosis in patients with inflammatory bowel disease: a retrospective study
title_fullStr	Cerebral venous sinus thrombosis in patients with inflammatory bowel disease: a retrospective study
title_full_unstemmed	Cerebral venous sinus thrombosis in patients with inflammatory bowel disease: a retrospective study
title_sort	cerebral venous sinus thrombosis in patients with inflammatory bowel disease: a retrospective study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a1a9a026ba5d4ca6864f35ed84ebf8df
work_keys_str_mv	AT wangshujun cerebralvenoussinusthrombosisinpatientswithinflammatoryboweldiseasearetrospectivestudy AT zhanghuijie cerebralvenoussinusthrombosisinpatientswithinflammatoryboweldiseasearetrospectivestudy AT baixia cerebralvenoussinusthrombosisinpatientswithinflammatoryboweldiseasearetrospectivestudy AT wanghongjian cerebralvenoussinusthrombosisinpatientswithinflammatoryboweldiseasearetrospectivestudy
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Cerebral venous sinus thrombosis in patients with inflammatory bowel disease: a retrospective study

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