Intrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions

Abstract Interestingly, some protein domains are intrinsically disordered (abbreviated as IDD), and the disorder degree of same domains may differ in different contexts. However, the evolutionary causes and biological significance of these phenomena are unclear. Here, we address these issues by geno...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chao Gao, Chong Ma, Huqiang Wang, Haolin Zhong, Jiayin Zang, Rugang Zhong, Fuchu He, Dong Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a1ae3b9da82c4b12ae74830b9620279b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a1ae3b9da82c4b12ae74830b9620279b
record_format	dspace
spelling	oai:doaj.org-article:a1ae3b9da82c4b12ae74830b9620279b2021-12-02T14:06:50ZIntrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions10.1038/s41598-021-82656-92045-2322https://doaj.org/article/a1ae3b9da82c4b12ae74830b9620279b2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82656-9https://doaj.org/toc/2045-2322Abstract Interestingly, some protein domains are intrinsically disordered (abbreviated as IDD), and the disorder degree of same domains may differ in different contexts. However, the evolutionary causes and biological significance of these phenomena are unclear. Here, we address these issues by genome-wide analyses of the evolutionary and functional features of IDDs in 1,870 species across the three superkingdoms. As the result, there is a significant positive correlation between the proportion of IDDs and organism complexity with some interesting exceptions. These phenomena may be due to the high disorder of clade-specific domains and the different disorder degrees of the domains shared in different clades. The functions of IDDs are clade-specific and the higher proportion of post-translational modification sites may contribute to their complex functions. Compared with metazoans, fungi have more IDDs with a consecutive disorder region but a low disorder ratio, which reflects their different functional requirements. As for disorder variation, it’s greater for domains among different proteins than those within the same proteins. Some clade-specific ‘no-variation’ or ‘high-variation’ domains are involved in clade-specific functions. In sum, intrinsic domain disorder is related to both the organism complexity and clade-specific functions. These results deepen the understanding of the evolution and function of IDDs.Chao GaoChong MaHuqiang WangHaolin ZhongJiayin ZangRugang ZhongFuchu HeDong YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chao Gao Chong Ma Huqiang Wang Haolin Zhong Jiayin Zang Rugang Zhong Fuchu He Dong Yang Intrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions
description	Abstract Interestingly, some protein domains are intrinsically disordered (abbreviated as IDD), and the disorder degree of same domains may differ in different contexts. However, the evolutionary causes and biological significance of these phenomena are unclear. Here, we address these issues by genome-wide analyses of the evolutionary and functional features of IDDs in 1,870 species across the three superkingdoms. As the result, there is a significant positive correlation between the proportion of IDDs and organism complexity with some interesting exceptions. These phenomena may be due to the high disorder of clade-specific domains and the different disorder degrees of the domains shared in different clades. The functions of IDDs are clade-specific and the higher proportion of post-translational modification sites may contribute to their complex functions. Compared with metazoans, fungi have more IDDs with a consecutive disorder region but a low disorder ratio, which reflects their different functional requirements. As for disorder variation, it’s greater for domains among different proteins than those within the same proteins. Some clade-specific ‘no-variation’ or ‘high-variation’ domains are involved in clade-specific functions. In sum, intrinsic domain disorder is related to both the organism complexity and clade-specific functions. These results deepen the understanding of the evolution and function of IDDs.
format	article
author	Chao Gao Chong Ma Huqiang Wang Haolin Zhong Jiayin Zang Rugang Zhong Fuchu He Dong Yang
author_facet	Chao Gao Chong Ma Huqiang Wang Haolin Zhong Jiayin Zang Rugang Zhong Fuchu He Dong Yang
author_sort	Chao Gao
title	Intrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions
title_short	Intrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions
title_full	Intrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions
title_fullStr	Intrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions
title_full_unstemmed	Intrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions
title_sort	intrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a1ae3b9da82c4b12ae74830b9620279b
work_keys_str_mv	AT chaogao intrinsicdisorderinproteindomainscontributestobothorganismcomplexityandcladespecificfunctions AT chongma intrinsicdisorderinproteindomainscontributestobothorganismcomplexityandcladespecificfunctions AT huqiangwang intrinsicdisorderinproteindomainscontributestobothorganismcomplexityandcladespecificfunctions AT haolinzhong intrinsicdisorderinproteindomainscontributestobothorganismcomplexityandcladespecificfunctions AT jiayinzang intrinsicdisorderinproteindomainscontributestobothorganismcomplexityandcladespecificfunctions AT rugangzhong intrinsicdisorderinproteindomainscontributestobothorganismcomplexityandcladespecificfunctions AT fuchuhe intrinsicdisorderinproteindomainscontributestobothorganismcomplexityandcladespecificfunctions AT dongyang intrinsicdisorderinproteindomainscontributestobothorganismcomplexityandcladespecificfunctions
_version_	1718391980358107136

Intrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions

Ejemplares similares