SUMO-mediated regulation of NLRP3 modulates inflammasome activity

SUMO-mediated regulation of NLRP3 modulates inflammasome activity

The NLRP3 inflammasome is an important component of inflammatory responses, but how it is negatively regulated is still unclear. Here the authors show that post-translational modification of NLRP3 by sumoylation suppresses inflammasome activity, and that desumoylation of NLRP3 by the SENP6 and SENP7...

Full description

Saved in:
Bibliographic Details
Main Authors: Rachael Barry, Sidonie Wicky John, Gianmaria Liccardi, Tencho Tenev, Isabel Jaco, Chih-Hong Chen, Justin Choi, Paulina Kasperkiewicz, Teresa Fernandes-Alnemri, Emad Alnemri, Marcin Drag, Yuan Chen, Pascal Meier
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
Q
Online Access:https://doaj.org/article/a1af958c12d44b05aa306bdfe595ee7f
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The NLRP3 inflammasome is an important component of inflammatory responses, but how it is negatively regulated is still unclear. Here the authors show that post-translational modification of NLRP3 by sumoylation suppresses inflammasome activity, and that desumoylation of NLRP3 by the SENP6 and SENP7 proteases promotes NLRP3 activation.

Similar Items