SUMO-mediated regulation of NLRP3 modulates inflammasome activity

The NLRP3 inflammasome is an important component of inflammatory responses, but how it is negatively regulated is still unclear. Here the authors show that post-translational modification of NLRP3 by sumoylation suppresses inflammasome activity, and that desumoylation of NLRP3 by the SENP6 and SENP7...

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Autores principales:	Rachael Barry, Sidonie Wicky John, Gianmaria Liccardi, Tencho Tenev, Isabel Jaco, Chih-Hong Chen, Justin Choi, Paulina Kasperkiewicz, Teresa Fernandes-Alnemri, Emad Alnemri, Marcin Drag, Yuan Chen, Pascal Meier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a1af958c12d44b05aa306bdfe595ee7f
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spelling	oai:doaj.org-article:a1af958c12d44b05aa306bdfe595ee7f2021-12-02T17:32:34ZSUMO-mediated regulation of NLRP3 modulates inflammasome activity10.1038/s41467-018-05321-22041-1723https://doaj.org/article/a1af958c12d44b05aa306bdfe595ee7f2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05321-2https://doaj.org/toc/2041-1723The NLRP3 inflammasome is an important component of inflammatory responses, but how it is negatively regulated is still unclear. Here the authors show that post-translational modification of NLRP3 by sumoylation suppresses inflammasome activity, and that desumoylation of NLRP3 by the SENP6 and SENP7 proteases promotes NLRP3 activation.Rachael BarrySidonie Wicky JohnGianmaria LiccardiTencho TenevIsabel JacoChih-Hong ChenJustin ChoiPaulina KasperkiewiczTeresa Fernandes-AlnemriEmad AlnemriMarcin DragYuan ChenPascal MeierNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rachael Barry Sidonie Wicky John Gianmaria Liccardi Tencho Tenev Isabel Jaco Chih-Hong Chen Justin Choi Paulina Kasperkiewicz Teresa Fernandes-Alnemri Emad Alnemri Marcin Drag Yuan Chen Pascal Meier SUMO-mediated regulation of NLRP3 modulates inflammasome activity
description	The NLRP3 inflammasome is an important component of inflammatory responses, but how it is negatively regulated is still unclear. Here the authors show that post-translational modification of NLRP3 by sumoylation suppresses inflammasome activity, and that desumoylation of NLRP3 by the SENP6 and SENP7 proteases promotes NLRP3 activation.
format	article
author	Rachael Barry Sidonie Wicky John Gianmaria Liccardi Tencho Tenev Isabel Jaco Chih-Hong Chen Justin Choi Paulina Kasperkiewicz Teresa Fernandes-Alnemri Emad Alnemri Marcin Drag Yuan Chen Pascal Meier
author_facet	Rachael Barry Sidonie Wicky John Gianmaria Liccardi Tencho Tenev Isabel Jaco Chih-Hong Chen Justin Choi Paulina Kasperkiewicz Teresa Fernandes-Alnemri Emad Alnemri Marcin Drag Yuan Chen Pascal Meier
author_sort	Rachael Barry
title	SUMO-mediated regulation of NLRP3 modulates inflammasome activity
title_short	SUMO-mediated regulation of NLRP3 modulates inflammasome activity
title_full	SUMO-mediated regulation of NLRP3 modulates inflammasome activity
title_fullStr	SUMO-mediated regulation of NLRP3 modulates inflammasome activity
title_full_unstemmed	SUMO-mediated regulation of NLRP3 modulates inflammasome activity
title_sort	sumo-mediated regulation of nlrp3 modulates inflammasome activity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a1af958c12d44b05aa306bdfe595ee7f
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SUMO-mediated regulation of NLRP3 modulates inflammasome activity

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