Elevated circulating FABP4 concentration predicts cardiovascular death in a general population: a 12-year prospective study

Abstract Fatty acid-binding protein 4 (FABP4) is secreted from adipose tissue and acts as an adipokine, and an elevated circulating FABP4 level is associated with metabolic disorders and atherosclerosis. However, little is known about the causal link between circulating FABP4 level and mortality in...

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Autores principales:	Norie Saito, Masato Furuhashi, Masayuki Koyama, Yukimura Higashiura, Hiroshi Akasaka, Marenao Tanaka, Norihito Moniwa, Hirofumi Ohnishi, Shigeyuki Saitoh, Nobuyuki Ura, Kazuaki Shimamoto, Tetsuji Miura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a1b163a29f68452081605024bd37debd
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spelling	oai:doaj.org-article:a1b163a29f68452081605024bd37debd2021-12-02T12:11:52ZElevated circulating FABP4 concentration predicts cardiovascular death in a general population: a 12-year prospective study10.1038/s41598-021-83494-52045-2322https://doaj.org/article/a1b163a29f68452081605024bd37debd2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83494-5https://doaj.org/toc/2045-2322Abstract Fatty acid-binding protein 4 (FABP4) is secreted from adipose tissue and acts as an adipokine, and an elevated circulating FABP4 level is associated with metabolic disorders and atherosclerosis. However, little is known about the causal link between circulating FABP4 level and mortality in a general population. We investigated the relationship between FABP4 concentration and mortality including cardiovascular death during a 12-year period in subjects of the Tanno-Sobetsu Study, a population-based cohort (n = 721, male/female: 302/419). FABP4 concentration at baseline was significantly higher in female subjects than in male subjects. All-cause death occurred in 123 (male/female: 74/49) subjects, and 34 (male/female: 20/14) and 42 (male/female: 26/16) subjects died of cardiovascular events and cancer, respectively. When divided into 3 groups according to tertiles of FABP4 level at baseline by sex (T1–T3), Kaplan–Meier survival curves showed that there were significant differences in rates of all-cause death and cardiovascular death, but not cancer death, among the groups. Multivariable Cox proportional hazard model analysis with a restricted cubic spline showed that hazard ratio (HR) for cardiovascular death, but not that for all-cause death, significantly increased with a higher FABP4 level at baseline after adjustment of age and sex. The risk of cardiovascular death after adjustment of age, sex, body mass index and levels of brain natriuretic peptide and high-sensitivity C-reactive protein in the 3rd tertile (T3) group (HR: 4.96, 95% confidence interval: 1.20–22.3) was significantly higher than that in the 1st tertile (T1) group as the reference. In conclusion, elevated circulating FABP4 concentration predicts cardiovascular death in a general population.Norie SaitoMasato FuruhashiMasayuki KoyamaYukimura HigashiuraHiroshi AkasakaMarenao TanakaNorihito MoniwaHirofumi OhnishiShigeyuki SaitohNobuyuki UraKazuaki ShimamotoTetsuji MiuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Norie Saito Masato Furuhashi Masayuki Koyama Yukimura Higashiura Hiroshi Akasaka Marenao Tanaka Norihito Moniwa Hirofumi Ohnishi Shigeyuki Saitoh Nobuyuki Ura Kazuaki Shimamoto Tetsuji Miura Elevated circulating FABP4 concentration predicts cardiovascular death in a general population: a 12-year prospective study
description	Abstract Fatty acid-binding protein 4 (FABP4) is secreted from adipose tissue and acts as an adipokine, and an elevated circulating FABP4 level is associated with metabolic disorders and atherosclerosis. However, little is known about the causal link between circulating FABP4 level and mortality in a general population. We investigated the relationship between FABP4 concentration and mortality including cardiovascular death during a 12-year period in subjects of the Tanno-Sobetsu Study, a population-based cohort (n = 721, male/female: 302/419). FABP4 concentration at baseline was significantly higher in female subjects than in male subjects. All-cause death occurred in 123 (male/female: 74/49) subjects, and 34 (male/female: 20/14) and 42 (male/female: 26/16) subjects died of cardiovascular events and cancer, respectively. When divided into 3 groups according to tertiles of FABP4 level at baseline by sex (T1–T3), Kaplan–Meier survival curves showed that there were significant differences in rates of all-cause death and cardiovascular death, but not cancer death, among the groups. Multivariable Cox proportional hazard model analysis with a restricted cubic spline showed that hazard ratio (HR) for cardiovascular death, but not that for all-cause death, significantly increased with a higher FABP4 level at baseline after adjustment of age and sex. The risk of cardiovascular death after adjustment of age, sex, body mass index and levels of brain natriuretic peptide and high-sensitivity C-reactive protein in the 3rd tertile (T3) group (HR: 4.96, 95% confidence interval: 1.20–22.3) was significantly higher than that in the 1st tertile (T1) group as the reference. In conclusion, elevated circulating FABP4 concentration predicts cardiovascular death in a general population.
format	article
author	Norie Saito Masato Furuhashi Masayuki Koyama Yukimura Higashiura Hiroshi Akasaka Marenao Tanaka Norihito Moniwa Hirofumi Ohnishi Shigeyuki Saitoh Nobuyuki Ura Kazuaki Shimamoto Tetsuji Miura
author_facet	Norie Saito Masato Furuhashi Masayuki Koyama Yukimura Higashiura Hiroshi Akasaka Marenao Tanaka Norihito Moniwa Hirofumi Ohnishi Shigeyuki Saitoh Nobuyuki Ura Kazuaki Shimamoto Tetsuji Miura
author_sort	Norie Saito
title	Elevated circulating FABP4 concentration predicts cardiovascular death in a general population: a 12-year prospective study
title_short	Elevated circulating FABP4 concentration predicts cardiovascular death in a general population: a 12-year prospective study
title_full	Elevated circulating FABP4 concentration predicts cardiovascular death in a general population: a 12-year prospective study
title_fullStr	Elevated circulating FABP4 concentration predicts cardiovascular death in a general population: a 12-year prospective study
title_full_unstemmed	Elevated circulating FABP4 concentration predicts cardiovascular death in a general population: a 12-year prospective study
title_sort	elevated circulating fabp4 concentration predicts cardiovascular death in a general population: a 12-year prospective study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a1b163a29f68452081605024bd37debd
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Elevated circulating FABP4 concentration predicts cardiovascular death in a general population: a 12-year prospective study

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