Centromere mechanical maturation during mammalian cell mitosis

During mitosis, tension at the centromere occurs from the spindle but the role of centromere mechanics in controlling metaphase tension is poorly understood. Here, the authors report that mechanical stiffnness of the centromere matures during mitotic progression and is amplified specifically at meta...

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Main Authors:	Lauren A. Harasymiw, Damien Tank, Mark McClellan, Neha Panigrahy, Melissa K. Gardner
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/a1b34f1f953d4020baee46b51bcab555
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spelling	oai:doaj.org-article:a1b34f1f953d4020baee46b51bcab5552021-12-02T14:38:58ZCentromere mechanical maturation during mammalian cell mitosis10.1038/s41467-019-09578-z2041-1723https://doaj.org/article/a1b34f1f953d4020baee46b51bcab5552019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09578-zhttps://doaj.org/toc/2041-1723During mitosis, tension at the centromere occurs from the spindle but the role of centromere mechanics in controlling metaphase tension is poorly understood. Here, the authors report that mechanical stiffnness of the centromere matures during mitotic progression and is amplified specifically at metaphase.Lauren A. HarasymiwDamien TankMark McClellanNeha PanigrahyMelissa K. GardnerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lauren A. Harasymiw Damien Tank Mark McClellan Neha Panigrahy Melissa K. Gardner Centromere mechanical maturation during mammalian cell mitosis
description	During mitosis, tension at the centromere occurs from the spindle but the role of centromere mechanics in controlling metaphase tension is poorly understood. Here, the authors report that mechanical stiffnness of the centromere matures during mitotic progression and is amplified specifically at metaphase.
format	article
author	Lauren A. Harasymiw Damien Tank Mark McClellan Neha Panigrahy Melissa K. Gardner
author_facet	Lauren A. Harasymiw Damien Tank Mark McClellan Neha Panigrahy Melissa K. Gardner
author_sort	Lauren A. Harasymiw
title	Centromere mechanical maturation during mammalian cell mitosis
title_short	Centromere mechanical maturation during mammalian cell mitosis
title_full	Centromere mechanical maturation during mammalian cell mitosis
title_fullStr	Centromere mechanical maturation during mammalian cell mitosis
title_full_unstemmed	Centromere mechanical maturation during mammalian cell mitosis
title_sort	centromere mechanical maturation during mammalian cell mitosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a1b34f1f953d4020baee46b51bcab555
work_keys_str_mv	AT laurenaharasymiw centromeremechanicalmaturationduringmammaliancellmitosis AT damientank centromeremechanicalmaturationduringmammaliancellmitosis AT markmcclellan centromeremechanicalmaturationduringmammaliancellmitosis AT nehapanigrahy centromeremechanicalmaturationduringmammaliancellmitosis AT melissakgardner centromeremechanicalmaturationduringmammaliancellmitosis
_version_	1718390787446669312

Centromere mechanical maturation during mammalian cell mitosis

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