Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data

Abstract Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been clinically investigated in Alzheimer’s disease (AD) and Lewy body dementia (LBD). However, the clinical effects are highly variable, which questions the suggested basic principles underlying these clinical trials....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Muhammad Nazmuddin, Ingrid H. C. H. M. Philippens, Teus van Laar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a1b733b4c17a496d932c032e07f85baf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a1b733b4c17a496d932c032e07f85baf
record_format	dspace
spelling	oai:doaj.org-article:a1b733b4c17a496d932c032e07f85baf2021-12-02T15:56:41ZElectrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data10.1038/s41598-021-91391-02045-2322https://doaj.org/article/a1b733b4c17a496d932c032e07f85baf2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91391-0https://doaj.org/toc/2045-2322Abstract Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been clinically investigated in Alzheimer’s disease (AD) and Lewy body dementia (LBD). However, the clinical effects are highly variable, which questions the suggested basic principles underlying these clinical trials. Therefore, preclinical and clinical data on the design of NBM stimulation experiments and its effects on behavioral and neurophysiological aspects are systematically reviewed here. Animal studies have shown that electrical stimulation of the NBM enhanced cognition, increased the release of acetylcholine, enhanced cerebral blood flow, released several neuroprotective factors, and facilitates plasticity of cortical and subcortical receptive fields. However, the translation of these outcomes to current clinical practice is hampered by the fact that mainly animals with an intact NBM were used, whereas most animals were stimulated unilaterally, with different stimulation paradigms for only restricted timeframes. Future animal research has to refine the NBM stimulation methods, using partially lesioned NBM nuclei, to better resemble the clinical situation in AD, and LBD. More preclinical data on the effect of stimulation of lesioned NBM should be present, before DBS of the NBM in human is explored further.Muhammad NazmuddinIngrid H. C. H. M. PhilippensTeus van LaarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Muhammad Nazmuddin Ingrid H. C. H. M. Philippens Teus van Laar Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data
description	Abstract Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been clinically investigated in Alzheimer’s disease (AD) and Lewy body dementia (LBD). However, the clinical effects are highly variable, which questions the suggested basic principles underlying these clinical trials. Therefore, preclinical and clinical data on the design of NBM stimulation experiments and its effects on behavioral and neurophysiological aspects are systematically reviewed here. Animal studies have shown that electrical stimulation of the NBM enhanced cognition, increased the release of acetylcholine, enhanced cerebral blood flow, released several neuroprotective factors, and facilitates plasticity of cortical and subcortical receptive fields. However, the translation of these outcomes to current clinical practice is hampered by the fact that mainly animals with an intact NBM were used, whereas most animals were stimulated unilaterally, with different stimulation paradigms for only restricted timeframes. Future animal research has to refine the NBM stimulation methods, using partially lesioned NBM nuclei, to better resemble the clinical situation in AD, and LBD. More preclinical data on the effect of stimulation of lesioned NBM should be present, before DBS of the NBM in human is explored further.
format	article
author	Muhammad Nazmuddin Ingrid H. C. H. M. Philippens Teus van Laar
author_facet	Muhammad Nazmuddin Ingrid H. C. H. M. Philippens Teus van Laar
author_sort	Muhammad Nazmuddin
title	Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data
title_short	Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data
title_full	Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data
title_fullStr	Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data
title_full_unstemmed	Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data
title_sort	electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a1b733b4c17a496d932c032e07f85baf
work_keys_str_mv	AT muhammadnazmuddin electricalstimulationofthenucleusbasalisofmeynertasystematicreviewofpreclinicalandclinicaldata AT ingridhchmphilippens electricalstimulationofthenucleusbasalisofmeynertasystematicreviewofpreclinicalandclinicaldata AT teusvanlaar electricalstimulationofthenucleusbasalisofmeynertasystematicreviewofpreclinicalandclinicaldata
_version_	1718385409364328448

Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data

Ejemplares similares