Value of the log odds of positive lymph nodes for prognostic assessment of colon mucinous adenocarcinoma: Analysis and external validation

Abstract Purpose To evaluate the impact of the log odds of positive lymph nodes (LODDS) on cancer‐specific survival (CSS) in colon mucinous adenocarcinoma (MAC) patients, compared with pN stage and the lymph nodes ratio (LNR). Methods A total of 10,182 colon MAC patients from the Surveillance, Epide...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Huajun Cai, Tianbao Xu, Zhicheng Zhuang, Yiyi Zhang, Yuan Gao, Xing Liu, Jinfu Zhuang, Yuanfeng Yang, Guoxian Guan
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	colon mucinous adenocarcinoma LODDS nomograms prognosis RPA stage Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a1b7a9b94e1c475184be482f5e0547b2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a1b7a9b94e1c475184be482f5e0547b2
record_format	dspace
spelling	oai:doaj.org-article:a1b7a9b94e1c475184be482f5e0547b22021-12-01T04:49:16ZValue of the log odds of positive lymph nodes for prognostic assessment of colon mucinous adenocarcinoma: Analysis and external validation2045-763410.1002/cam4.4366https://doaj.org/article/a1b7a9b94e1c475184be482f5e0547b22021-12-01T00:00:00Zhttps://doi.org/10.1002/cam4.4366https://doaj.org/toc/2045-7634Abstract Purpose To evaluate the impact of the log odds of positive lymph nodes (LODDS) on cancer‐specific survival (CSS) in colon mucinous adenocarcinoma (MAC) patients, compared with pN stage and the lymph nodes ratio (LNR). Methods A total of 10,182 colon MAC patients from the Surveillance, Epidemiology, and End Results database were divided into the training group. The external validation group included 153 patients from Fujian Medical University Union Hospital. The Cox regression method was used to identify prognostic risk factors. Nomograms were evaluated by Harrell's concordance index (C‐index) and calibration curves. Recursive partitioning analysis (RPA) was used to develop a novel staging system. Results Time‐dependent receiver operating characteristic curves (ROC) to predict CSS showed the areas under the ROC curve of LODDS were always higher than pN stage and LNR. LNR and LODDS classifications can well distinguish the prognosis of patients with the same pN stage. Cox analyses indicated that age, tumor size, pT stage, pN stage, LNR, and LODDS were independent predictors of CSS (p < 0.05). Based on three lymph nodes classifications, we constructed three prognostic nomograms models for CSS. The C‐index of the pN, LNR, and LODDS classification nomograms were 0.746 (95% confidence interval [95% CI]: 0.736–0.756), 0.750 (95% CI: 0.740–0.760), and 0.758 (95% CI: 0.748–0.768), respectively. In external validation, we observed the C‐index of LODDS classification nomograms was 0.787 (95% CI: 0.648–0.926). RPA stage, including four stages, was constructed successfully based on pT stage and LNR or LODDS, respectively. The 3‐, 5‐, and 8‐year areas under the ROC curve of LNR‐RPA stage and LODDS‐RPA stage were superior to tumor‐node‐metastasis stage. Conclusion LODDS to be a better prognostic factor of CSS for colon MAC patients than pN stage and LNR. A nomogram and RPA stage base on LODDS can provide accurate information for personalized cancer treatment.Huajun CaiTianbao XuZhicheng ZhuangYiyi ZhangYuan GaoXing LiuJinfu ZhuangYuanfeng YangGuoxian GuanWileyarticlecolon mucinous adenocarcinomaLODDSnomogramsprognosisRPA stageNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 23, Pp 8542-8557 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colon mucinous adenocarcinoma LODDS nomograms prognosis RPA stage Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	colon mucinous adenocarcinoma LODDS nomograms prognosis RPA stage Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Huajun Cai Tianbao Xu Zhicheng Zhuang Yiyi Zhang Yuan Gao Xing Liu Jinfu Zhuang Yuanfeng Yang Guoxian Guan Value of the log odds of positive lymph nodes for prognostic assessment of colon mucinous adenocarcinoma: Analysis and external validation
description	Abstract Purpose To evaluate the impact of the log odds of positive lymph nodes (LODDS) on cancer‐specific survival (CSS) in colon mucinous adenocarcinoma (MAC) patients, compared with pN stage and the lymph nodes ratio (LNR). Methods A total of 10,182 colon MAC patients from the Surveillance, Epidemiology, and End Results database were divided into the training group. The external validation group included 153 patients from Fujian Medical University Union Hospital. The Cox regression method was used to identify prognostic risk factors. Nomograms were evaluated by Harrell's concordance index (C‐index) and calibration curves. Recursive partitioning analysis (RPA) was used to develop a novel staging system. Results Time‐dependent receiver operating characteristic curves (ROC) to predict CSS showed the areas under the ROC curve of LODDS were always higher than pN stage and LNR. LNR and LODDS classifications can well distinguish the prognosis of patients with the same pN stage. Cox analyses indicated that age, tumor size, pT stage, pN stage, LNR, and LODDS were independent predictors of CSS (p < 0.05). Based on three lymph nodes classifications, we constructed three prognostic nomograms models for CSS. The C‐index of the pN, LNR, and LODDS classification nomograms were 0.746 (95% confidence interval [95% CI]: 0.736–0.756), 0.750 (95% CI: 0.740–0.760), and 0.758 (95% CI: 0.748–0.768), respectively. In external validation, we observed the C‐index of LODDS classification nomograms was 0.787 (95% CI: 0.648–0.926). RPA stage, including four stages, was constructed successfully based on pT stage and LNR or LODDS, respectively. The 3‐, 5‐, and 8‐year areas under the ROC curve of LNR‐RPA stage and LODDS‐RPA stage were superior to tumor‐node‐metastasis stage. Conclusion LODDS to be a better prognostic factor of CSS for colon MAC patients than pN stage and LNR. A nomogram and RPA stage base on LODDS can provide accurate information for personalized cancer treatment.
format	article
author	Huajun Cai Tianbao Xu Zhicheng Zhuang Yiyi Zhang Yuan Gao Xing Liu Jinfu Zhuang Yuanfeng Yang Guoxian Guan
author_facet	Huajun Cai Tianbao Xu Zhicheng Zhuang Yiyi Zhang Yuan Gao Xing Liu Jinfu Zhuang Yuanfeng Yang Guoxian Guan
author_sort	Huajun Cai
title	Value of the log odds of positive lymph nodes for prognostic assessment of colon mucinous adenocarcinoma: Analysis and external validation
title_short	Value of the log odds of positive lymph nodes for prognostic assessment of colon mucinous adenocarcinoma: Analysis and external validation
title_full	Value of the log odds of positive lymph nodes for prognostic assessment of colon mucinous adenocarcinoma: Analysis and external validation
title_fullStr	Value of the log odds of positive lymph nodes for prognostic assessment of colon mucinous adenocarcinoma: Analysis and external validation
title_full_unstemmed	Value of the log odds of positive lymph nodes for prognostic assessment of colon mucinous adenocarcinoma: Analysis and external validation
title_sort	value of the log odds of positive lymph nodes for prognostic assessment of colon mucinous adenocarcinoma: analysis and external validation
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/a1b7a9b94e1c475184be482f5e0547b2
work_keys_str_mv	AT huajuncai valueofthelogoddsofpositivelymphnodesforprognosticassessmentofcolonmucinousadenocarcinomaanalysisandexternalvalidation AT tianbaoxu valueofthelogoddsofpositivelymphnodesforprognosticassessmentofcolonmucinousadenocarcinomaanalysisandexternalvalidation AT zhichengzhuang valueofthelogoddsofpositivelymphnodesforprognosticassessmentofcolonmucinousadenocarcinomaanalysisandexternalvalidation AT yiyizhang valueofthelogoddsofpositivelymphnodesforprognosticassessmentofcolonmucinousadenocarcinomaanalysisandexternalvalidation AT yuangao valueofthelogoddsofpositivelymphnodesforprognosticassessmentofcolonmucinousadenocarcinomaanalysisandexternalvalidation AT xingliu valueofthelogoddsofpositivelymphnodesforprognosticassessmentofcolonmucinousadenocarcinomaanalysisandexternalvalidation AT jinfuzhuang valueofthelogoddsofpositivelymphnodesforprognosticassessmentofcolonmucinousadenocarcinomaanalysisandexternalvalidation AT yuanfengyang valueofthelogoddsofpositivelymphnodesforprognosticassessmentofcolonmucinousadenocarcinomaanalysisandexternalvalidation AT guoxianguan valueofthelogoddsofpositivelymphnodesforprognosticassessmentofcolonmucinousadenocarcinomaanalysisandexternalvalidation
_version_	1718405740608094208

Value of the log odds of positive lymph nodes for prognostic assessment of colon mucinous adenocarcinoma: Analysis and external validation

Ejemplares similares