Plasma Homocysteine Level in Children under Treatment with Antiepileptic Drugs and its Relation to Intelligence Quotient

Background: Epilepsy is one of the most common neurological disorders in children. It often requires long-term antiepileptic drug (AED) therapy. AEDs are frequently associated with cognitive and behavioral dysfunctions. Also, there is a relationship between AEDs use and homocysteine levels. Elevated...

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Autores principales:	Mohammed Abo Al-maaty, Mohamed Elmazahy, Tarek Emran, Hany El-khaleegy
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2020
Materias:	epilepsy antiepileptic drugs homocysteine cognition intelligence quotient Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a1b80aa94116425dafefe2b3f8f4317f
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spelling	oai:doaj.org-article:a1b80aa94116425dafefe2b3f8f4317f2021-12-02T10:38:27ZPlasma Homocysteine Level in Children under Treatment with Antiepileptic Drugs and its Relation to Intelligence Quotient2636-41742682-378010.21608/ijma.2020.16455.1029https://doaj.org/article/a1b80aa94116425dafefe2b3f8f4317f2020-01-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_67647_842e04c67fe7fb02f31696fb269cd856.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Epilepsy is one of the most common neurological disorders in children. It often requires long-term antiepileptic drug (AED) therapy. AEDs are frequently associated with cognitive and behavioral dysfunctions. Also, there is a relationship between AEDs use and homocysteine levels. Elevated homocysteine has been associated with cognitive dysfunction. However, such effect among epileptic children has not been well-studied. Aim of the work: To study plasma homocysteine level in children under treatment with AEDs and its relation to intelligence quotient (IQ). Patients and Methods: A case control study included 56 epileptic children on AED therapy for at least 6 months, and 36 healthy children (Controls). Study was conducted at Al-Azhar University Hospital (Damietta) from June 2016 to June 2018. Plasma homocysteine was measured using Enzymatic Recycling (Biotecnica Instruments SpA). IQ testing was conducted using Stanford-Binet Intelligence Scales, Fifth Edition. Results: Epileptic children exhibited significant elevation of Homocysteine level (P=0.005), and significant affection of all IQ parameters. There was significant negative correlation between homocysteine level with total working memory, total verbal IQ and total IQ. Multivariate regression analysis revealed that homocysteine showed a significant and independent association with total working memory, total verbal IQ and total IQ. None of the other studied factors revealed such association. Conclusion: Homocysteine was a significant and independent risk factor for low total working memory score, low total Verbal IQ and low total IQ scores. Further studies are required to confirm these results, and to evaluate the effect of homocysteine-lowering treatment on cognitive function in epileptic children.Mohammed Abo Al-maatyMohamed ElmazahyTarek EmranHany El-khaleegyAl-Azhar University, Faculty of Medicine (Damietta)articleepilepsyantiepileptic drugshomocysteinecognitionintelligence quotientMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 2, Iss 1, Pp 223-231 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	epilepsy antiepileptic drugs homocysteine cognition intelligence quotient Medicine (General) R5-920
spellingShingle	epilepsy antiepileptic drugs homocysteine cognition intelligence quotient Medicine (General) R5-920 Mohammed Abo Al-maaty Mohamed Elmazahy Tarek Emran Hany El-khaleegy Plasma Homocysteine Level in Children under Treatment with Antiepileptic Drugs and its Relation to Intelligence Quotient
description	Background: Epilepsy is one of the most common neurological disorders in children. It often requires long-term antiepileptic drug (AED) therapy. AEDs are frequently associated with cognitive and behavioral dysfunctions. Also, there is a relationship between AEDs use and homocysteine levels. Elevated homocysteine has been associated with cognitive dysfunction. However, such effect among epileptic children has not been well-studied. Aim of the work: To study plasma homocysteine level in children under treatment with AEDs and its relation to intelligence quotient (IQ). Patients and Methods: A case control study included 56 epileptic children on AED therapy for at least 6 months, and 36 healthy children (Controls). Study was conducted at Al-Azhar University Hospital (Damietta) from June 2016 to June 2018. Plasma homocysteine was measured using Enzymatic Recycling (Biotecnica Instruments SpA). IQ testing was conducted using Stanford-Binet Intelligence Scales, Fifth Edition. Results: Epileptic children exhibited significant elevation of Homocysteine level (P=0.005), and significant affection of all IQ parameters. There was significant negative correlation between homocysteine level with total working memory, total verbal IQ and total IQ. Multivariate regression analysis revealed that homocysteine showed a significant and independent association with total working memory, total verbal IQ and total IQ. None of the other studied factors revealed such association. Conclusion: Homocysteine was a significant and independent risk factor for low total working memory score, low total Verbal IQ and low total IQ scores. Further studies are required to confirm these results, and to evaluate the effect of homocysteine-lowering treatment on cognitive function in epileptic children.
format	article
author	Mohammed Abo Al-maaty Mohamed Elmazahy Tarek Emran Hany El-khaleegy
author_facet	Mohammed Abo Al-maaty Mohamed Elmazahy Tarek Emran Hany El-khaleegy
author_sort	Mohammed Abo Al-maaty
title	Plasma Homocysteine Level in Children under Treatment with Antiepileptic Drugs and its Relation to Intelligence Quotient
title_short	Plasma Homocysteine Level in Children under Treatment with Antiepileptic Drugs and its Relation to Intelligence Quotient
title_full	Plasma Homocysteine Level in Children under Treatment with Antiepileptic Drugs and its Relation to Intelligence Quotient
title_fullStr	Plasma Homocysteine Level in Children under Treatment with Antiepileptic Drugs and its Relation to Intelligence Quotient
title_full_unstemmed	Plasma Homocysteine Level in Children under Treatment with Antiepileptic Drugs and its Relation to Intelligence Quotient
title_sort	plasma homocysteine level in children under treatment with antiepileptic drugs and its relation to intelligence quotient
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2020
url	https://doaj.org/article/a1b80aa94116425dafefe2b3f8f4317f
work_keys_str_mv	AT mohammedaboalmaaty plasmahomocysteinelevelinchildrenundertreatmentwithantiepilepticdrugsanditsrelationtointelligencequotient AT mohamedelmazahy plasmahomocysteinelevelinchildrenundertreatmentwithantiepilepticdrugsanditsrelationtointelligencequotient AT tarekemran plasmahomocysteinelevelinchildrenundertreatmentwithantiepilepticdrugsanditsrelationtointelligencequotient AT hanyelkhaleegy plasmahomocysteinelevelinchildrenundertreatmentwithantiepilepticdrugsanditsrelationtointelligencequotient
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Plasma Homocysteine Level in Children under Treatment with Antiepileptic Drugs and its Relation to Intelligence Quotient

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