LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy

Abstract Genetically engineered pigs are a promising source for islet cell transplantation in type 1 diabetes, but the strong human anti-pig immune response prevents its successful clinical application. Here we studied the efficacy of neonatal porcine islet-like cell clusters (NPICCs) overexpressing...

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Autores principales: L. Wolf-van Buerck, M. Schuster, F. S. Oduncu, A. Baehr, T. Mayr, S. Guethoff, J. Abicht, B. Reichart, N. Klymiuk, E. Wolf, J. Seissler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/a1bd3d97a7a849b2a03c593d11b1bf93
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