MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLS

Contact sensitivity is a classical T cell-mediated, clinically important phenomenon elicited by small molecular weight molecules (haptens) that bind to host proteins to form a complete antigen. In our model experiments, contact sensitivity was produced in CBA mice, by means of cutaneous sensitizatio...

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Auteurs principaux:	S. I. Pavlova, D. Z. Albegova, A. A. Kyagova, I. G. Kozlov
Format:	article
Langue:	RU
Publié:	SPb RAACI 2014
Sujets:	licorice root flavonoids contact sensitivity adoptive transfer Immunologic diseases. Allergy RC581-607
Accès en ligne:	https://doaj.org/article/a1bfd098f91440f4a0be3fb932b56c1b
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spelling	oai:doaj.org-article:a1bfd098f91440f4a0be3fb932b56c1b2021-11-18T08:03:41ZMECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLS1563-06252313-741X10.15789/1563-0625-2010-6-503-510https://doaj.org/article/a1bfd098f91440f4a0be3fb932b56c1b2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/439https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XContact sensitivity is a classical T cell-mediated, clinically important phenomenon elicited by small molecular weight molecules (haptens) that bind to host proteins to form a complete antigen. In our model experiments, contact sensitivity was produced in CBA mice, by means of cutaneous sensitization with 2.4-dinitrofluorobenzene. We used an adoptive transfer of contact sensitivity with different populations of splenocytes, in order to detect immunosuppressive effects of licorice (Glycyrrhizae) root flavonoids. Suppression of adoptive transfer of contact sensitivity in mice-recipients to different degree was found, when applying the flavonoids. It was revealed, that this effect depends on the type of target population interacting with flavonoids. We have also demonstrate, that licorice root flavonoids do not induce apoptosis of effector cells.S. I. PavlovaD. Z. AlbegovaA. A. KyagovaI. G. KozlovSPb RAACIarticlelicorice root flavonoidscontact sensitivityadoptive transferImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 6, Pp 503-510 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	licorice root flavonoids contact sensitivity adoptive transfer Immunologic diseases. Allergy RC581-607
spellingShingle	licorice root flavonoids contact sensitivity adoptive transfer Immunologic diseases. Allergy RC581-607 S. I. Pavlova D. Z. Albegova A. A. Kyagova I. G. Kozlov MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLS
description	Contact sensitivity is a classical T cell-mediated, clinically important phenomenon elicited by small molecular weight molecules (haptens) that bind to host proteins to form a complete antigen. In our model experiments, contact sensitivity was produced in CBA mice, by means of cutaneous sensitization with 2.4-dinitrofluorobenzene. We used an adoptive transfer of contact sensitivity with different populations of splenocytes, in order to detect immunosuppressive effects of licorice (Glycyrrhizae) root flavonoids. Suppression of adoptive transfer of contact sensitivity in mice-recipients to different degree was found, when applying the flavonoids. It was revealed, that this effect depends on the type of target population interacting with flavonoids. We have also demonstrate, that licorice root flavonoids do not induce apoptosis of effector cells.
format	article
author	S. I. Pavlova D. Z. Albegova A. A. Kyagova I. G. Kozlov
author_facet	S. I. Pavlova D. Z. Albegova A. A. Kyagova I. G. Kozlov
author_sort	S. I. Pavlova
title	MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLS
title_short	MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLS
title_full	MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLS
title_fullStr	MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLS
title_full_unstemmed	MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLS
title_sort	mechanisms of immunosuppressive action of licorice root flavonoids in contact sensitivity in mice: inhibition of t lymphocyte effector function mediated by non- effector cells
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/a1bfd098f91440f4a0be3fb932b56c1b
work_keys_str_mv	AT sipavlova mechanismsofimmunosuppressiveactionoflicoricerootflavonoidsincontactsensitivityinmiceinhibitionoftlymphocyteeffectorfunctionmediatedbynoneffectorcells AT dzalbegova mechanismsofimmunosuppressiveactionoflicoricerootflavonoidsincontactsensitivityinmiceinhibitionoftlymphocyteeffectorfunctionmediatedbynoneffectorcells AT aakyagova mechanismsofimmunosuppressiveactionoflicoricerootflavonoidsincontactsensitivityinmiceinhibitionoftlymphocyteeffectorfunctionmediatedbynoneffectorcells AT igkozlov mechanismsofimmunosuppressiveactionoflicoricerootflavonoidsincontactsensitivityinmiceinhibitionoftlymphocyteeffectorfunctionmediatedbynoneffectorcells
_version_	1718422496095502336

MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLS

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