Volatile organic compounds in uremia.

<h4>Background</h4>Although "uremic fetor" has long been felt to be diagnostic of renal failure, the compounds exhaled in uremia remain largely unknown so far. The present work investigates whether breath analysis by ion mobility spectrometry can be used for the identification...

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Autores principales:	Nikolaos Pagonas, Wolfgang Vautz, Luzia Seifert, Rafael Slodzinski, Joachim Jankowski, Walter Zidek, Timm H Westhoff
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a1c191a0066e4993898628666db03dfa
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spelling	oai:doaj.org-article:a1c191a0066e4993898628666db03dfa2021-11-18T08:14:00ZVolatile organic compounds in uremia.1932-620310.1371/journal.pone.0046258https://doaj.org/article/a1c191a0066e4993898628666db03dfa2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23049998/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Although "uremic fetor" has long been felt to be diagnostic of renal failure, the compounds exhaled in uremia remain largely unknown so far. The present work investigates whether breath analysis by ion mobility spectrometry can be used for the identification of volatile organic compounds retained in uremia.<h4>Methods</h4>Breath analysis was performed in 28 adults with an eGFR ≥ 60 ml/min per 1.73 m(2), 26 adults with chronic renal failure corresponding to an eGFR of 10-59 ml/min per 1.73 m(2), and 28 adults with end-stage renal disease (ESRD) before and after a hemodialysis session. Breath analysis was performed by ion mobility spectrometryafter gas-chromatographic preseparation. Identification of the compounds of interest was performed by thermal desorption gas chromatography/mass spectrometry.<h4>Results</h4>Breath analyses revealed significant differences in the spectra of patients with and without renal failure. Thirteen compounds were chosen for further evaluation. Some compounds including hydroxyacetone, 3-hydroxy-2-butanone and ammonia accumulated with decreasing renal function and were eliminated by dialysis. The concentrations of these compounds allowed a significant differentiation between healthy, chronic renal failure with an eGFR of 10-59 ml/min, and ESRD (p<0.05 each). Other compounds including 4-heptanal, 4-heptanone, and 2-heptanone preferentially or exclusively occurred in patients undergoing hemodialysis.<h4>Conclusion</h4>Impairment of renal function induces a characteristic fingerprint of volatile compounds in the breath. The technique of ion mobility spectrometry can be used for the identification of lipophilic uremic retention molecules.Nikolaos PagonasWolfgang VautzLuzia SeifertRafael SlodzinskiJoachim JankowskiWalter ZidekTimm H WesthoffPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e46258 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nikolaos Pagonas Wolfgang Vautz Luzia Seifert Rafael Slodzinski Joachim Jankowski Walter Zidek Timm H Westhoff Volatile organic compounds in uremia.
description	<h4>Background</h4>Although "uremic fetor" has long been felt to be diagnostic of renal failure, the compounds exhaled in uremia remain largely unknown so far. The present work investigates whether breath analysis by ion mobility spectrometry can be used for the identification of volatile organic compounds retained in uremia.<h4>Methods</h4>Breath analysis was performed in 28 adults with an eGFR ≥ 60 ml/min per 1.73 m(2), 26 adults with chronic renal failure corresponding to an eGFR of 10-59 ml/min per 1.73 m(2), and 28 adults with end-stage renal disease (ESRD) before and after a hemodialysis session. Breath analysis was performed by ion mobility spectrometryafter gas-chromatographic preseparation. Identification of the compounds of interest was performed by thermal desorption gas chromatography/mass spectrometry.<h4>Results</h4>Breath analyses revealed significant differences in the spectra of patients with and without renal failure. Thirteen compounds were chosen for further evaluation. Some compounds including hydroxyacetone, 3-hydroxy-2-butanone and ammonia accumulated with decreasing renal function and were eliminated by dialysis. The concentrations of these compounds allowed a significant differentiation between healthy, chronic renal failure with an eGFR of 10-59 ml/min, and ESRD (p<0.05 each). Other compounds including 4-heptanal, 4-heptanone, and 2-heptanone preferentially or exclusively occurred in patients undergoing hemodialysis.<h4>Conclusion</h4>Impairment of renal function induces a characteristic fingerprint of volatile compounds in the breath. The technique of ion mobility spectrometry can be used for the identification of lipophilic uremic retention molecules.
format	article
author	Nikolaos Pagonas Wolfgang Vautz Luzia Seifert Rafael Slodzinski Joachim Jankowski Walter Zidek Timm H Westhoff
author_facet	Nikolaos Pagonas Wolfgang Vautz Luzia Seifert Rafael Slodzinski Joachim Jankowski Walter Zidek Timm H Westhoff
author_sort	Nikolaos Pagonas
title	Volatile organic compounds in uremia.
title_short	Volatile organic compounds in uremia.
title_full	Volatile organic compounds in uremia.
title_fullStr	Volatile organic compounds in uremia.
title_full_unstemmed	Volatile organic compounds in uremia.
title_sort	volatile organic compounds in uremia.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a1c191a0066e4993898628666db03dfa
work_keys_str_mv	AT nikolaospagonas volatileorganiccompoundsinuremia AT wolfgangvautz volatileorganiccompoundsinuremia AT luziaseifert volatileorganiccompoundsinuremia AT rafaelslodzinski volatileorganiccompoundsinuremia AT joachimjankowski volatileorganiccompoundsinuremia AT walterzidek volatileorganiccompoundsinuremia AT timmhwesthoff volatileorganiccompoundsinuremia
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Volatile organic compounds in uremia.

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