Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation

Previous work has shown in iPSC derived neurons that synaptic impairments are associated with a 4bp DISC1 deletion. Here the authors demonstrate a role for the PDE4 signalling pathway in these synaptic impairments.

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Autores principales:	Nam-Shik Kim, Zhexing Wen, Jing Liu, Ying Zhou, Ziyuan Guo, Chongchong Xu, Yu-Ting Lin, Ki-Jun Yoon, Junhyun Park, Michelle Cho, Minji Kim, Xinyuan Wang, Huimei Yu, Srilatha Salamuru, Kimberly M. Christian, Kuei-sen Hsu, Menghang Xia, Weidong Li, Christopher A. Ross, Russell L. Margolis, Xin-Yun Lu, Hongjun Song, Guo-li Ming
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a1c93081300b4869a2a2b16a518720f6
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spelling	oai:doaj.org-article:a1c93081300b4869a2a2b16a518720f62021-12-02T13:14:53ZPharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation10.1038/s41467-021-21713-32041-1723https://doaj.org/article/a1c93081300b4869a2a2b16a518720f62021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21713-3https://doaj.org/toc/2041-1723Previous work has shown in iPSC derived neurons that synaptic impairments are associated with a 4bp DISC1 deletion. Here the authors demonstrate a role for the PDE4 signalling pathway in these synaptic impairments.Nam-Shik KimZhexing WenJing LiuYing ZhouZiyuan GuoChongchong XuYu-Ting LinKi-Jun YoonJunhyun ParkMichelle ChoMinji KimXinyuan WangHuimei YuSrilatha SalamuruKimberly M. ChristianKuei-sen HsuMenghang XiaWeidong LiChristopher A. RossRussell L. MargolisXin-Yun LuHongjun SongGuo-li MingNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nam-Shik Kim Zhexing Wen Jing Liu Ying Zhou Ziyuan Guo Chongchong Xu Yu-Ting Lin Ki-Jun Yoon Junhyun Park Michelle Cho Minji Kim Xinyuan Wang Huimei Yu Srilatha Salamuru Kimberly M. Christian Kuei-sen Hsu Menghang Xia Weidong Li Christopher A. Ross Russell L. Margolis Xin-Yun Lu Hongjun Song Guo-li Ming Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation
description	Previous work has shown in iPSC derived neurons that synaptic impairments are associated with a 4bp DISC1 deletion. Here the authors demonstrate a role for the PDE4 signalling pathway in these synaptic impairments.
format	article
author	Nam-Shik Kim Zhexing Wen Jing Liu Ying Zhou Ziyuan Guo Chongchong Xu Yu-Ting Lin Ki-Jun Yoon Junhyun Park Michelle Cho Minji Kim Xinyuan Wang Huimei Yu Srilatha Salamuru Kimberly M. Christian Kuei-sen Hsu Menghang Xia Weidong Li Christopher A. Ross Russell L. Margolis Xin-Yun Lu Hongjun Song Guo-li Ming
author_facet	Nam-Shik Kim Zhexing Wen Jing Liu Ying Zhou Ziyuan Guo Chongchong Xu Yu-Ting Lin Ki-Jun Yoon Junhyun Park Michelle Cho Minji Kim Xinyuan Wang Huimei Yu Srilatha Salamuru Kimberly M. Christian Kuei-sen Hsu Menghang Xia Weidong Li Christopher A. Ross Russell L. Margolis Xin-Yun Lu Hongjun Song Guo-li Ming
author_sort	Nam-Shik Kim
title	Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation
title_short	Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation
title_full	Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation
title_fullStr	Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation
title_full_unstemmed	Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation
title_sort	pharmacological rescue in patient ipsc and mouse models with a rare disc1 mutation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a1c93081300b4869a2a2b16a518720f6
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Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation

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