Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?

Inflammatory bowel disease (IBD), Crohn’s disease, and ulcerative colitis are characterized by chronic and relapsing inflammation, while their pathogenesis remains mostly unelucidated. Gut commensal microbiota seem to be one of the various implicated factors, as several studies have shown a signific...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eirini Filidou, George Kolios
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	probiotics intestinal wound healing gut microbiota mucosal healing inflammatory bowel disease Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/a1d038f3866f4012a2647d05beeb77a9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a1d038f3866f4012a2647d05beeb77a9
record_format	dspace
spelling	oai:doaj.org-article:a1d038f3866f4012a2647d05beeb77a92021-11-25T18:39:58ZProbiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?10.3390/ph141111811424-8247https://doaj.org/article/a1d038f3866f4012a2647d05beeb77a92021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1181https://doaj.org/toc/1424-8247Inflammatory bowel disease (IBD), Crohn’s disease, and ulcerative colitis are characterized by chronic and relapsing inflammation, while their pathogenesis remains mostly unelucidated. Gut commensal microbiota seem to be one of the various implicated factors, as several studies have shown a significant decrease in the microbiome diversity of patients with IBD. Although the question of whether microbiota dysbiosis is a causal factor or the result of chronic inflammation remains unanswered, one fact is clear; active inflammation in IBD results in the disruption of the mucus layer structure, barrier function, and also, colonization sites. Recently, many studies on IBD have been focusing on the interplay between mucosal and luminal microbiota, underlining their possible beneficial effect on mucosal healing. Regarding this notion, it has now been shown that specific probiotic strains, when administrated, lead to significantly decreased inflammation, amelioration of colitis, and improved mucosal healing. Probiotics are live microorganisms exerting beneficial effects on the host’s health when administered in adequate quantity. The aim of this review was to present and discuss the current findings on the role of gut microbiota and their metabolites in intestinal wound healing and the effects of probiotics on intestinal mucosal wound closure.Eirini FilidouGeorge KoliosMDPI AGarticleprobioticsintestinal wound healinggut microbiotamucosal healinginflammatory bowel diseaseMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1181, p 1181 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	probiotics intestinal wound healing gut microbiota mucosal healing inflammatory bowel disease Medicine R Pharmacy and materia medica RS1-441
spellingShingle	probiotics intestinal wound healing gut microbiota mucosal healing inflammatory bowel disease Medicine R Pharmacy and materia medica RS1-441 Eirini Filidou George Kolios Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?
description	Inflammatory bowel disease (IBD), Crohn’s disease, and ulcerative colitis are characterized by chronic and relapsing inflammation, while their pathogenesis remains mostly unelucidated. Gut commensal microbiota seem to be one of the various implicated factors, as several studies have shown a significant decrease in the microbiome diversity of patients with IBD. Although the question of whether microbiota dysbiosis is a causal factor or the result of chronic inflammation remains unanswered, one fact is clear; active inflammation in IBD results in the disruption of the mucus layer structure, barrier function, and also, colonization sites. Recently, many studies on IBD have been focusing on the interplay between mucosal and luminal microbiota, underlining their possible beneficial effect on mucosal healing. Regarding this notion, it has now been shown that specific probiotic strains, when administrated, lead to significantly decreased inflammation, amelioration of colitis, and improved mucosal healing. Probiotics are live microorganisms exerting beneficial effects on the host’s health when administered in adequate quantity. The aim of this review was to present and discuss the current findings on the role of gut microbiota and their metabolites in intestinal wound healing and the effects of probiotics on intestinal mucosal wound closure.
format	article
author	Eirini Filidou George Kolios
author_facet	Eirini Filidou George Kolios
author_sort	Eirini Filidou
title	Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?
title_short	Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?
title_full	Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?
title_fullStr	Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?
title_full_unstemmed	Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?
title_sort	probiotics in intestinal mucosal healing: a new therapy or an old friend?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a1d038f3866f4012a2647d05beeb77a9
work_keys_str_mv	AT eirinifilidou probioticsinintestinalmucosalhealinganewtherapyoranoldfriend AT georgekolios probioticsinintestinalmucosalhealinganewtherapyoranoldfriend
_version_	1718410853403852800

Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?

Ejemplares similares