Prevalence Rates and Risk Factors for Primary Open Angle Glaucoma in the Middle East

Abstract Glaucoma is a multifactorial disease and a leading cause of irreversible blindness worldwide. Current data has demonstrated the approximate distribution of primary open-angle glaucoma (POAG) in patients of European, African, Hispanic, and Eastern Asian descent. However, a significant gap in...

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Autores principales:	Rana Torabi, Alon Harris, Brent Siesky, Ryan Zukerman, Francesco Oddone, Sunu Mathew, Ingrida Januleviciene, Alice C. Verticchio Vercellin
Formato:	article
Lenguaje:	EN
Publicado:	Knowledge E 2021
Materias:	epidemiology glaucoma middle east prevalence risk factors Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a1d6663e39a949d3824c50a74f4baa3b
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spelling	oai:doaj.org-article:a1d6663e39a949d3824c50a74f4baa3b2021-11-09T08:05:35ZPrevalence Rates and Risk Factors for Primary Open Angle Glaucoma in the Middle East2008-20102008-322X10.18502/jovr.v16i4.9755https://doaj.org/article/a1d6663e39a949d3824c50a74f4baa3b2021-10-01T00:00:00Zhttps://doi.org/10.18502/jovr.v16i4.9755https://doaj.org/toc/2008-2010https://doaj.org/toc/2008-322XAbstract Glaucoma is a multifactorial disease and a leading cause of irreversible blindness worldwide. Current data has demonstrated the approximate distribution of primary open-angle glaucoma (POAG) in patients of European, African, Hispanic, and Eastern Asian descent. However, a significant gap in the literature exists regarding the prevalence of POAG in Middle Eastern (ME) populations. Current studies estimate ME POAG prevalence based on a European model. Herein we screened 65 total publications on ME prevalence of POAG and specific risk factors using keywords: “glaucoma”, “prevalence”, “incidence”, “risk factor”, “Middle East”, “Mideast”, “Persian”, “Far East”, as well as searching by individual ME countries through PubMed, Embase, Ovid, Scopus, and Trip searches with additional reference list searches from relevant articles published up to and including March 1, 2021. Fifty qualifying records were included after 15 studies identified with low statistical power, confounding co-morbid ophthalmic diseases, and funding bias were excluded. Studies of ME glaucoma risk factors that identify chromosomes, familial trend, age/gender, socioeconomic status, lifestyle, intraocular pressure, vascular influences, optic disc hemorrhage, cup-to-disc ratio, blood pressure, obstructive sleep apnea, and diabetes mellitus were included in this systematic review. We conclude that the prevalence of POAG in the ME is likely higher than the prevalence rate that European models suggest, with ME specific risk factors likely playing a role. However, these findings are severely limited by the paucity of population-level data in the ME. Well-designed, longitudinal population-based studies with rigorous inclusion and exclusion criteria are ultimately needed to accurately assess the epidemiology and specific mechanistic risk factors of glaucoma in ME populations.Rana TorabiAlon HarrisBrent SieskyRyan ZukermanFrancesco OddoneSunu MathewIngrida JanulevicieneAlice C. Verticchio VercellinKnowledge Earticleepidemiologyglaucomamiddle eastprevalencerisk factorsOphthalmologyRE1-994ENJournal of Ophthalmic & Vision Research, Vol 16, Iss 4, Pp 644-656 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epidemiology glaucoma middle east prevalence risk factors Ophthalmology RE1-994
spellingShingle	epidemiology glaucoma middle east prevalence risk factors Ophthalmology RE1-994 Rana Torabi Alon Harris Brent Siesky Ryan Zukerman Francesco Oddone Sunu Mathew Ingrida Januleviciene Alice C. Verticchio Vercellin Prevalence Rates and Risk Factors for Primary Open Angle Glaucoma in the Middle East
description	Abstract Glaucoma is a multifactorial disease and a leading cause of irreversible blindness worldwide. Current data has demonstrated the approximate distribution of primary open-angle glaucoma (POAG) in patients of European, African, Hispanic, and Eastern Asian descent. However, a significant gap in the literature exists regarding the prevalence of POAG in Middle Eastern (ME) populations. Current studies estimate ME POAG prevalence based on a European model. Herein we screened 65 total publications on ME prevalence of POAG and specific risk factors using keywords: “glaucoma”, “prevalence”, “incidence”, “risk factor”, “Middle East”, “Mideast”, “Persian”, “Far East”, as well as searching by individual ME countries through PubMed, Embase, Ovid, Scopus, and Trip searches with additional reference list searches from relevant articles published up to and including March 1, 2021. Fifty qualifying records were included after 15 studies identified with low statistical power, confounding co-morbid ophthalmic diseases, and funding bias were excluded. Studies of ME glaucoma risk factors that identify chromosomes, familial trend, age/gender, socioeconomic status, lifestyle, intraocular pressure, vascular influences, optic disc hemorrhage, cup-to-disc ratio, blood pressure, obstructive sleep apnea, and diabetes mellitus were included in this systematic review. We conclude that the prevalence of POAG in the ME is likely higher than the prevalence rate that European models suggest, with ME specific risk factors likely playing a role. However, these findings are severely limited by the paucity of population-level data in the ME. Well-designed, longitudinal population-based studies with rigorous inclusion and exclusion criteria are ultimately needed to accurately assess the epidemiology and specific mechanistic risk factors of glaucoma in ME populations.
format	article
author	Rana Torabi Alon Harris Brent Siesky Ryan Zukerman Francesco Oddone Sunu Mathew Ingrida Januleviciene Alice C. Verticchio Vercellin
author_facet	Rana Torabi Alon Harris Brent Siesky Ryan Zukerman Francesco Oddone Sunu Mathew Ingrida Januleviciene Alice C. Verticchio Vercellin
author_sort	Rana Torabi
title	Prevalence Rates and Risk Factors for Primary Open Angle Glaucoma in the Middle East
title_short	Prevalence Rates and Risk Factors for Primary Open Angle Glaucoma in the Middle East
title_full	Prevalence Rates and Risk Factors for Primary Open Angle Glaucoma in the Middle East
title_fullStr	Prevalence Rates and Risk Factors for Primary Open Angle Glaucoma in the Middle East
title_full_unstemmed	Prevalence Rates and Risk Factors for Primary Open Angle Glaucoma in the Middle East
title_sort	prevalence rates and risk factors for primary open angle glaucoma in the middle east
publisher	Knowledge E
publishDate	2021
url	https://doaj.org/article/a1d6663e39a949d3824c50a74f4baa3b
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Prevalence Rates and Risk Factors for Primary Open Angle Glaucoma in the Middle East

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