Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering

Josh Neman1, Amanda Hambrecht2, Cherie Cadry3, Rahul Jandial11Department of Neurosurgery, Beckman Research Institute, City of Hope National Cancer Center, Duarte, 2Department of Biological Sciences, University of Southern California, Los Angeles, 3Department of Public Health Sciences, University of...

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Autores principales:	Neman J, Hambrecht A, Cadry C, Jandial R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a1db44314c014d03b4c8ca9669ffe22f
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spelling	oai:doaj.org-article:a1db44314c014d03b4c8ca9669ffe22f2021-12-02T02:59:14ZStem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering1177-54751177-5491https://doaj.org/article/a1db44314c014d03b4c8ca9669ffe22f2012-03-01T00:00:00Zhttp://www.dovepress.com/stem-cellndashmediated-osteogenesis-therapeutic-potential-for-bone-tis-a9447https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Josh Neman1, Amanda Hambrecht2, Cherie Cadry3, Rahul Jandial11Department of Neurosurgery, Beckman Research Institute, City of Hope National Cancer Center, Duarte, 2Department of Biological Sciences, University of Southern California, Los Angeles, 3Department of Public Health Sciences, University of California, Irvine, California, USAAbstract: Intervertebral disc degeneration often requires bony spinal fusion for long-term relief. Current arthrodesis procedures use bone grafts from autogenous bone, allogenic backed bone, or synthetic materials. Autogenous bone grafts can result in donor site morbidity and pain at the donor site, while allogenic backed bone and synthetic materials have variable effectiveness. Given these limitations, researchers have focused on new treatments that will allow for safe and successful bone repair and regeneration. Mesenchymal stem cells have received attention for their ability to differentiate into osteoblasts, cells that synthesize new bone. With the recent advances in scaffold and biomaterial technology as well as stem cell manipulation and transplantation, stem cells and their scaffolds are uniquely positioned to bring about significant improvements in the treatment and outcomes of spinal fusion and other injuries.Keywords: mesenchymal stem cell, osteogenesis, scaffolds, bone morphogenetic protein, Wnt, autograft, osteoblastNeman JHambrecht ACadry CJandial RDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2012, Iss default, Pp 47-57 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Neman J Hambrecht A Cadry C Jandial R Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering
description	Josh Neman1, Amanda Hambrecht2, Cherie Cadry3, Rahul Jandial11Department of Neurosurgery, Beckman Research Institute, City of Hope National Cancer Center, Duarte, 2Department of Biological Sciences, University of Southern California, Los Angeles, 3Department of Public Health Sciences, University of California, Irvine, California, USAAbstract: Intervertebral disc degeneration often requires bony spinal fusion for long-term relief. Current arthrodesis procedures use bone grafts from autogenous bone, allogenic backed bone, or synthetic materials. Autogenous bone grafts can result in donor site morbidity and pain at the donor site, while allogenic backed bone and synthetic materials have variable effectiveness. Given these limitations, researchers have focused on new treatments that will allow for safe and successful bone repair and regeneration. Mesenchymal stem cells have received attention for their ability to differentiate into osteoblasts, cells that synthesize new bone. With the recent advances in scaffold and biomaterial technology as well as stem cell manipulation and transplantation, stem cells and their scaffolds are uniquely positioned to bring about significant improvements in the treatment and outcomes of spinal fusion and other injuries.Keywords: mesenchymal stem cell, osteogenesis, scaffolds, bone morphogenetic protein, Wnt, autograft, osteoblast
format	article
author	Neman J Hambrecht A Cadry C Jandial R
author_facet	Neman J Hambrecht A Cadry C Jandial R
author_sort	Neman J
title	Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering
title_short	Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering
title_full	Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering
title_fullStr	Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering
title_full_unstemmed	Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering
title_sort	stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/a1db44314c014d03b4c8ca9669ffe22f
work_keys_str_mv	AT nemanj stemcellmediatedosteogenesistherapeuticpotentialforbonetissueengineering AT hambrechta stemcellmediatedosteogenesistherapeuticpotentialforbonetissueengineering AT cadryc stemcellmediatedosteogenesistherapeuticpotentialforbonetissueengineering AT jandialr stemcellmediatedosteogenesistherapeuticpotentialforbonetissueengineering
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Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering

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