Аntibacterial inorganic agents: efficiency of using multicomponent systems

Metal and metal oxide nanoparticles (NPs) are promising antibacterial agents. They have a broad antimicrobial activity against both Gram-positive and Gram-negative bacteria, viruses, and protozoans. The use of NPs reduces the possibility of the microbial resistance development. This review briefly s...

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Autores principales:	А. A. Meleshko, A. G. Afinogenova, G. E. Afinogenov, A. A. Spiridonova, V. P. Tolstoy
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2020
Materias:	metal-based nanoparticles nanocomposites antimicrobial activity antibiotic resistance microbial biofilms long-term activity Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/a1dbe3e16a1140568b32f09305ff07fd
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spelling	oai:doaj.org-article:a1dbe3e16a1140568b32f09305ff07fd2021-11-22T07:09:55ZАntibacterial inorganic agents: efficiency of using multicomponent systems2220-76192313-739810.15789/2220-7619-AIA-1512https://doaj.org/article/a1dbe3e16a1140568b32f09305ff07fd2020-11-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1512https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Metal and metal oxide nanoparticles (NPs) are promising antibacterial agents. They have a broad antimicrobial activity against both Gram-positive and Gram-negative bacteria, viruses, and protozoans. The use of NPs reduces the possibility of the microbial resistance development. This review briefly shows the general mechanisms and the main factors of antibacterial activity of NPs. In this article, a comprehensive review of the recent researches in the field of new antimicrobial agents with superior long-term bactericidal activity and low toxicity is provided. The review gives the examples of synthesis of double and triple nanocomposites based on following oxides: CuO, ZnO, Fe3O4, Ag2O, MnO2, etc. including metal and nonmetal doped nanocomposites (for example with Ag, Ce, Cr, Mn, Nd, Co, Sn, Fe, N, F, etc.). Compared with bactericidal action of individual oxides, the nanocomposites demonstrate superior antibacterial activity and have synergistic effects. For example, the antimicrobial activity of ZnO against both Gram-positive and Gram-negative bacteria was increased by -100% by formation of triple nanocomposites ZnO—MnO2—Cu2O or ZnO—Ag2O—Ag2S. Similar effect was showed for Ce-doped ZnO and Zn-doped CuO. The present article also provides the examples of nanocomposites containing NPs and organic (chitosan, cellulose, polyvinylpyrrolidone, biopolymers, etc.) or inorganic materials with special structure (graphene oxide, TiO2 nanotubes, silica) which demonstrate controlled release and longterm antibacterial activity. All of the considered nanocomposites and their combinations have a pronounced long-term antimicrobial effect including against antibiotic-resistant strains. They are able to prevent the formation of microbial biofilms on biotic and abiotic surfaces, have low toxicity to eukaryotic cells, demonstrate anti-inflammatory and woundhealing properties in compositions with polymers (sodium alginate, collagen, polyvinylpyrrolidone, etc.). The use of nanoscale systems can solve several important practical problems at the same time: saving of long-term antimicrobial activities while reducing the number of compounds, creation of new antimicrobial agents with low toxicity and reduced environmental impact, development of new biocidal materials, including new coatings for effective antimicrobial protection of medical devices.А. A. MeleshkoA. G. AfinogenovaG. E. AfinogenovA. A. SpiridonovaV. P. TolstoySankt-Peterburg : NIIÈM imeni Pasteraarticlemetal-based nanoparticlesnanocompositesantimicrobial activityantibiotic resistancemicrobial biofilmslong-term activityInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 10, Iss 4, Pp 639-654 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	metal-based nanoparticles nanocomposites antimicrobial activity antibiotic resistance microbial biofilms long-term activity Infectious and parasitic diseases RC109-216
spellingShingle	metal-based nanoparticles nanocomposites antimicrobial activity antibiotic resistance microbial biofilms long-term activity Infectious and parasitic diseases RC109-216 А. A. Meleshko A. G. Afinogenova G. E. Afinogenov A. A. Spiridonova V. P. Tolstoy Аntibacterial inorganic agents: efficiency of using multicomponent systems
description	Metal and metal oxide nanoparticles (NPs) are promising antibacterial agents. They have a broad antimicrobial activity against both Gram-positive and Gram-negative bacteria, viruses, and protozoans. The use of NPs reduces the possibility of the microbial resistance development. This review briefly shows the general mechanisms and the main factors of antibacterial activity of NPs. In this article, a comprehensive review of the recent researches in the field of new antimicrobial agents with superior long-term bactericidal activity and low toxicity is provided. The review gives the examples of synthesis of double and triple nanocomposites based on following oxides: CuO, ZnO, Fe3O4, Ag2O, MnO2, etc. including metal and nonmetal doped nanocomposites (for example with Ag, Ce, Cr, Mn, Nd, Co, Sn, Fe, N, F, etc.). Compared with bactericidal action of individual oxides, the nanocomposites demonstrate superior antibacterial activity and have synergistic effects. For example, the antimicrobial activity of ZnO against both Gram-positive and Gram-negative bacteria was increased by -100% by formation of triple nanocomposites ZnO—MnO2—Cu2O or ZnO—Ag2O—Ag2S. Similar effect was showed for Ce-doped ZnO and Zn-doped CuO. The present article also provides the examples of nanocomposites containing NPs and organic (chitosan, cellulose, polyvinylpyrrolidone, biopolymers, etc.) or inorganic materials with special structure (graphene oxide, TiO2 nanotubes, silica) which demonstrate controlled release and longterm antibacterial activity. All of the considered nanocomposites and their combinations have a pronounced long-term antimicrobial effect including against antibiotic-resistant strains. They are able to prevent the formation of microbial biofilms on biotic and abiotic surfaces, have low toxicity to eukaryotic cells, demonstrate anti-inflammatory and woundhealing properties in compositions with polymers (sodium alginate, collagen, polyvinylpyrrolidone, etc.). The use of nanoscale systems can solve several important practical problems at the same time: saving of long-term antimicrobial activities while reducing the number of compounds, creation of new antimicrobial agents with low toxicity and reduced environmental impact, development of new biocidal materials, including new coatings for effective antimicrobial protection of medical devices.
format	article
author	А. A. Meleshko A. G. Afinogenova G. E. Afinogenov A. A. Spiridonova V. P. Tolstoy
author_facet	А. A. Meleshko A. G. Afinogenova G. E. Afinogenov A. A. Spiridonova V. P. Tolstoy
author_sort	А. A. Meleshko
title	Аntibacterial inorganic agents: efficiency of using multicomponent systems
title_short	Аntibacterial inorganic agents: efficiency of using multicomponent systems
title_full	Аntibacterial inorganic agents: efficiency of using multicomponent systems
title_fullStr	Аntibacterial inorganic agents: efficiency of using multicomponent systems
title_full_unstemmed	Аntibacterial inorganic agents: efficiency of using multicomponent systems
title_sort	аntibacterial inorganic agents: efficiency of using multicomponent systems
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2020
url	https://doaj.org/article/a1dbe3e16a1140568b32f09305ff07fd
work_keys_str_mv	AT aameleshko antibacterialinorganicagentsefficiencyofusingmulticomponentsystems AT agafinogenova antibacterialinorganicagentsefficiencyofusingmulticomponentsystems AT geafinogenov antibacterialinorganicagentsefficiencyofusingmulticomponentsystems AT aaspiridonova antibacterialinorganicagentsefficiencyofusingmulticomponentsystems AT vptolstoy antibacterialinorganicagentsefficiencyofusingmulticomponentsystems
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Аntibacterial inorganic agents: efficiency of using multicomponent systems

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