Mycobacterial dynamin-like protein IniA mediates membrane fission

Tuberculosis drugs induce the expression of IniA, but so far little has been known about its structure and function. Here the authors present the apo and GTP bound crystal structures of Mycobacterium smegmatis IniA, which folds as a bacterial dynamin-like protein and show that IniA mediates membrane...

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Autores principales:	Manfu Wang, Xiangyang Guo, Xiuna Yang, Bing Zhang, Jie Ren, Aijun Liu, Yajun Ran, Bing Yan, Fang Chen, Luke W. Guddat, Junjie Hu, Jun Li, Zihe Rao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a1dcbbca4dc249008861d887755f12f9
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spelling	oai:doaj.org-article:a1dcbbca4dc249008861d887755f12f92021-12-02T17:01:38ZMycobacterial dynamin-like protein IniA mediates membrane fission10.1038/s41467-019-11860-z2041-1723https://doaj.org/article/a1dcbbca4dc249008861d887755f12f92019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11860-zhttps://doaj.org/toc/2041-1723Tuberculosis drugs induce the expression of IniA, but so far little has been known about its structure and function. Here the authors present the apo and GTP bound crystal structures of Mycobacterium smegmatis IniA, which folds as a bacterial dynamin-like protein and show that IniA mediates membrane fission in vitro.Manfu WangXiangyang GuoXiuna YangBing ZhangJie RenAijun LiuYajun RanBing YanFang ChenLuke W. GuddatJunjie HuJun LiZihe RaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manfu Wang Xiangyang Guo Xiuna Yang Bing Zhang Jie Ren Aijun Liu Yajun Ran Bing Yan Fang Chen Luke W. Guddat Junjie Hu Jun Li Zihe Rao Mycobacterial dynamin-like protein IniA mediates membrane fission
description	Tuberculosis drugs induce the expression of IniA, but so far little has been known about its structure and function. Here the authors present the apo and GTP bound crystal structures of Mycobacterium smegmatis IniA, which folds as a bacterial dynamin-like protein and show that IniA mediates membrane fission in vitro.
format	article
author	Manfu Wang Xiangyang Guo Xiuna Yang Bing Zhang Jie Ren Aijun Liu Yajun Ran Bing Yan Fang Chen Luke W. Guddat Junjie Hu Jun Li Zihe Rao
author_facet	Manfu Wang Xiangyang Guo Xiuna Yang Bing Zhang Jie Ren Aijun Liu Yajun Ran Bing Yan Fang Chen Luke W. Guddat Junjie Hu Jun Li Zihe Rao
author_sort	Manfu Wang
title	Mycobacterial dynamin-like protein IniA mediates membrane fission
title_short	Mycobacterial dynamin-like protein IniA mediates membrane fission
title_full	Mycobacterial dynamin-like protein IniA mediates membrane fission
title_fullStr	Mycobacterial dynamin-like protein IniA mediates membrane fission
title_full_unstemmed	Mycobacterial dynamin-like protein IniA mediates membrane fission
title_sort	mycobacterial dynamin-like protein inia mediates membrane fission
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a1dcbbca4dc249008861d887755f12f9
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Mycobacterial dynamin-like protein IniA mediates membrane fission

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