Patient characteristics and outcomes associated with adherence to the low PEEP/FIO2 table for acute respiratory distress syndrome

Abstract It remains uncertain how best to set positive end-expiratory pressure (PEEP) for mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). Among patients on low tidal volume ventilation (LTVV), we investigated if further adherence to the low PEEP/FIO2 (inspired o...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kay Choong See, Juliet Sahagun, Juvel Taculod
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a1e7602fbb9c48eaa09b54bae2e76ff2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a1e7602fbb9c48eaa09b54bae2e76ff2
record_format	dspace
spelling	oai:doaj.org-article:a1e7602fbb9c48eaa09b54bae2e76ff22021-12-02T16:08:06ZPatient characteristics and outcomes associated with adherence to the low PEEP/FIO2 table for acute respiratory distress syndrome10.1038/s41598-021-94081-z2045-2322https://doaj.org/article/a1e7602fbb9c48eaa09b54bae2e76ff22021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94081-zhttps://doaj.org/toc/2045-2322Abstract It remains uncertain how best to set positive end-expiratory pressure (PEEP) for mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). Among patients on low tidal volume ventilation (LTVV), we investigated if further adherence to the low PEEP/FIO2 (inspired oxygen fraction) table would be associated with better survival compared to nonadherence. Patients with ARDS, admitted directly from the Emergency Department to our 20-bed Medical Intensive Care Unit (ICU) from August 2016 to July 2017, were retrospectively studied. To determine adherence to the low PEEP/FIO2 table, PEEP and FIO2 12 h after ICU admission were used, to reflect ventilator adjustments by ICU clinicians after initial stabilization. Logistic regression was used to analyze hospital mortality as an outcome with adherence to the low PEEP/FIO2 as the key independent variable, adjusted for age, APACHE II score, initial P/F ratio and initial systolic blood pressure. 138 patients with ARDS were analysed. Overall adherence to the low PEEP/FIO2 table was 75.4%. Among patients on LTVV, nonadherence to the low PEEP/FIO2 table was associated with increased mortality compared to adherence (adjusted odds ratio 4.10, 95% confidence interval 1.68–9.99, P = 0.002). Patient characteristics at baseline were not associated with adherence to the low PEEP/FIO2 table.Kay Choong SeeJuliet SahagunJuvel TaculodNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kay Choong See Juliet Sahagun Juvel Taculod Patient characteristics and outcomes associated with adherence to the low PEEP/FIO2 table for acute respiratory distress syndrome
description	Abstract It remains uncertain how best to set positive end-expiratory pressure (PEEP) for mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). Among patients on low tidal volume ventilation (LTVV), we investigated if further adherence to the low PEEP/FIO2 (inspired oxygen fraction) table would be associated with better survival compared to nonadherence. Patients with ARDS, admitted directly from the Emergency Department to our 20-bed Medical Intensive Care Unit (ICU) from August 2016 to July 2017, were retrospectively studied. To determine adherence to the low PEEP/FIO2 table, PEEP and FIO2 12 h after ICU admission were used, to reflect ventilator adjustments by ICU clinicians after initial stabilization. Logistic regression was used to analyze hospital mortality as an outcome with adherence to the low PEEP/FIO2 as the key independent variable, adjusted for age, APACHE II score, initial P/F ratio and initial systolic blood pressure. 138 patients with ARDS were analysed. Overall adherence to the low PEEP/FIO2 table was 75.4%. Among patients on LTVV, nonadherence to the low PEEP/FIO2 table was associated with increased mortality compared to adherence (adjusted odds ratio 4.10, 95% confidence interval 1.68–9.99, P = 0.002). Patient characteristics at baseline were not associated with adherence to the low PEEP/FIO2 table.
format	article
author	Kay Choong See Juliet Sahagun Juvel Taculod
author_facet	Kay Choong See Juliet Sahagun Juvel Taculod
author_sort	Kay Choong See
title	Patient characteristics and outcomes associated with adherence to the low PEEP/FIO2 table for acute respiratory distress syndrome
title_short	Patient characteristics and outcomes associated with adherence to the low PEEP/FIO2 table for acute respiratory distress syndrome
title_full	Patient characteristics and outcomes associated with adherence to the low PEEP/FIO2 table for acute respiratory distress syndrome
title_fullStr	Patient characteristics and outcomes associated with adherence to the low PEEP/FIO2 table for acute respiratory distress syndrome
title_full_unstemmed	Patient characteristics and outcomes associated with adherence to the low PEEP/FIO2 table for acute respiratory distress syndrome
title_sort	patient characteristics and outcomes associated with adherence to the low peep/fio2 table for acute respiratory distress syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a1e7602fbb9c48eaa09b54bae2e76ff2
work_keys_str_mv	AT kaychoongsee patientcharacteristicsandoutcomesassociatedwithadherencetothelowpeepfio2tableforacuterespiratorydistresssyndrome AT julietsahagun patientcharacteristicsandoutcomesassociatedwithadherencetothelowpeepfio2tableforacuterespiratorydistresssyndrome AT juveltaculod patientcharacteristicsandoutcomesassociatedwithadherencetothelowpeepfio2tableforacuterespiratorydistresssyndrome
_version_	1718384613914574848

Patient characteristics and outcomes associated with adherence to the low PEEP/FIO2 table for acute respiratory distress syndrome

Ejemplares similares