Selenium and thyroid autoimmunity
Roberto NegroDepartment of Endocrinology, “V. Fazzi” Hospital, Lecce, ItalyAbstract: The trace element selenium (Se) occurs in the form of the amino acid selenocysteine in selenoproteins. Selenoproteins exerts multiple physiological effects in human health, many of which...
Guardado en:
| Autor principal: | |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2008
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/a1e8378eef364d8fa0d235865776c0bd |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:a1e8378eef364d8fa0d235865776c0bd |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:a1e8378eef364d8fa0d235865776c0bd2021-12-02T05:17:41ZSelenium and thyroid autoimmunity1177-54751177-5491https://doaj.org/article/a1e8378eef364d8fa0d235865776c0bd2008-06-01T00:00:00Zhttp://www.dovepress.com/selenium-and-thyroid-autoimmunity-a1731https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Roberto NegroDepartment of Endocrinology, “V. Fazzi” Hospital, Lecce, ItalyAbstract: The trace element selenium (Se) occurs in the form of the amino acid selenocysteine in selenoproteins. Selenoproteins exerts multiple physiological effects in human health, many of which are related with regulation of reduction-oxidation processes. In fact, the selenoenzyme families of glutathione peroxidase (GPx) and thioredoxin reductase (TRx) display the ability to act as antioxidants, protecting cells from oxidative damage. Furthermore, another class of selenoproteins are the iodothyronine deiodinase enzymes (DIO), which catalyze the conversion of thyroxine (T4) in triiodothyronine (T3), then exerting a fine tuned control on thyroid hormones metabolism. Several studies have investigated the potential positive effects of Se supplementation in thyroid diseases, characterized by increased levels of hydrogen peroxide and free radicals, like autoimmune chronic thyroiditis. These studies have supplied evidences indicating that Se supplementation, maximizing the antioxidant enzymes activity, may reduce the thyroid inflammatory status. Then, it may be postulated that Se could play a therapeutical role in thyroid autoimmune diseases. Despite the fact that recent studies seem to be concordant about Se beneficial effects in decreasing thyroid peroxidase antibodies (TPOAb) titers and ameliorating the ultrasound echogenicity pattern, several doubts have to be still clarified, before advising Se supplementation in chronic autoimmune thyroiditis.Keywords: selenium, thyroid, autoimmunity Roberto NegroDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2008, Iss Issue 2, Pp 265-273 (2008) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine (General) R5-920 |
| spellingShingle |
Medicine (General) R5-920 Roberto Negro Selenium and thyroid autoimmunity |
| description |
Roberto NegroDepartment of Endocrinology, “V. Fazzi” Hospital, Lecce, ItalyAbstract: The trace element selenium (Se) occurs in the form of the amino acid selenocysteine in selenoproteins. Selenoproteins exerts multiple physiological effects in human health, many of which are related with regulation of reduction-oxidation processes. In fact, the selenoenzyme families of glutathione peroxidase (GPx) and thioredoxin reductase (TRx) display the ability to act as antioxidants, protecting cells from oxidative damage. Furthermore, another class of selenoproteins are the iodothyronine deiodinase enzymes (DIO), which catalyze the conversion of thyroxine (T4) in triiodothyronine (T3), then exerting a fine tuned control on thyroid hormones metabolism. Several studies have investigated the potential positive effects of Se supplementation in thyroid diseases, characterized by increased levels of hydrogen peroxide and free radicals, like autoimmune chronic thyroiditis. These studies have supplied evidences indicating that Se supplementation, maximizing the antioxidant enzymes activity, may reduce the thyroid inflammatory status. Then, it may be postulated that Se could play a therapeutical role in thyroid autoimmune diseases. Despite the fact that recent studies seem to be concordant about Se beneficial effects in decreasing thyroid peroxidase antibodies (TPOAb) titers and ameliorating the ultrasound echogenicity pattern, several doubts have to be still clarified, before advising Se supplementation in chronic autoimmune thyroiditis.Keywords: selenium, thyroid, autoimmunity |
| format |
article |
| author |
Roberto Negro |
| author_facet |
Roberto Negro |
| author_sort |
Roberto Negro |
| title |
Selenium and thyroid autoimmunity |
| title_short |
Selenium and thyroid autoimmunity |
| title_full |
Selenium and thyroid autoimmunity |
| title_fullStr |
Selenium and thyroid autoimmunity |
| title_full_unstemmed |
Selenium and thyroid autoimmunity |
| title_sort |
selenium and thyroid autoimmunity |
| publisher |
Dove Medical Press |
| publishDate |
2008 |
| url |
https://doaj.org/article/a1e8378eef364d8fa0d235865776c0bd |
| work_keys_str_mv |
AT robertonegro seleniumandthyroidautoimmunity |
| _version_ |
1718400487387037696 |