Histopathological and electron microscopic study for different grades of inferior oblique muscle overaction

Momen M Hamdi,1 Golzamine R El-Hawary,1 Nadia G El-Hefnawy,2 Manal I Salman21Ophthalmology Department, 2Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, EgyptPurpose: To correlate between the clinical degree of inferior oblique muscle (IO) overaction and the histopathological...

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Autores principales:	Hamdi MM, El-Hawary GR, El-Hefnawy NG, Salman MI
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a1e9ba9cf3fd461fb55c7d1a95535ed2
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spelling	oai:doaj.org-article:a1e9ba9cf3fd461fb55c7d1a95535ed22021-12-02T02:05:57ZHistopathological and electron microscopic study for different grades of inferior oblique muscle overaction1177-54671177-5483https://doaj.org/article/a1e9ba9cf3fd461fb55c7d1a95535ed22013-05-01T00:00:00Zhttp://www.dovepress.com/histopathological-and-electron-microscopic-study-for-different-grades--a13105https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Momen M Hamdi,1 Golzamine R El-Hawary,1 Nadia G El-Hefnawy,2 Manal I Salman21Ophthalmology Department, 2Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, EgyptPurpose: To correlate between the clinical degree of inferior oblique muscle (IO) overaction and the histopathological changes of the muscle.Settings: Departments of Ophthalmology and Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.Patients and methods: Biopsies from 12 IO muscles were taken during strabismus surgery for cases of IO muscle overaction. One biopsy from a normal IO was taken as a control. All samples were examined under light microscopy and transmission electron microscopy.Results: In light microscopy, all cases showed histopathological changes, in the form of degenerated and regenerating muscle fibers, increased fibrofatty infiltration, and mild variability of muscle fiber size. Hypertrophied nerve bundles also appeared in biopsies from patients with grade II and grade III IO overaction. Endomysial and perimysial fibrosis, mononuclear inflammatory infiltrates, and focal fatty infiltration were seen in biopsies from cases of grade III IO overaction. In electron microscopy, ultrastructural examination revealed an increased number of mitochondria associated with some degree of mitochondrial pleomorphism. Hypercontracted fibers, vacuoles, and fat droplets were also noticed.Conclusion: IO overaction is always accompanied by histopathological changes that differ in severity according to the clinical grading of the overaction. Changes in nerve fibers can also occur in severe cases.Keywords: inferior oblique, electron microscope, overaction, histopathological, muscle fibersHamdi MMEl-Hawary GREl-Hefnawy NGSalman MIDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 917-921 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Hamdi MM El-Hawary GR El-Hefnawy NG Salman MI Histopathological and electron microscopic study for different grades of inferior oblique muscle overaction
description	Momen M Hamdi,1 Golzamine R El-Hawary,1 Nadia G El-Hefnawy,2 Manal I Salman21Ophthalmology Department, 2Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, EgyptPurpose: To correlate between the clinical degree of inferior oblique muscle (IO) overaction and the histopathological changes of the muscle.Settings: Departments of Ophthalmology and Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.Patients and methods: Biopsies from 12 IO muscles were taken during strabismus surgery for cases of IO muscle overaction. One biopsy from a normal IO was taken as a control. All samples were examined under light microscopy and transmission electron microscopy.Results: In light microscopy, all cases showed histopathological changes, in the form of degenerated and regenerating muscle fibers, increased fibrofatty infiltration, and mild variability of muscle fiber size. Hypertrophied nerve bundles also appeared in biopsies from patients with grade II and grade III IO overaction. Endomysial and perimysial fibrosis, mononuclear inflammatory infiltrates, and focal fatty infiltration were seen in biopsies from cases of grade III IO overaction. In electron microscopy, ultrastructural examination revealed an increased number of mitochondria associated with some degree of mitochondrial pleomorphism. Hypercontracted fibers, vacuoles, and fat droplets were also noticed.Conclusion: IO overaction is always accompanied by histopathological changes that differ in severity according to the clinical grading of the overaction. Changes in nerve fibers can also occur in severe cases.Keywords: inferior oblique, electron microscope, overaction, histopathological, muscle fibers
format	article
author	Hamdi MM El-Hawary GR El-Hefnawy NG Salman MI
author_facet	Hamdi MM El-Hawary GR El-Hefnawy NG Salman MI
author_sort	Hamdi MM
title	Histopathological and electron microscopic study for different grades of inferior oblique muscle overaction
title_short	Histopathological and electron microscopic study for different grades of inferior oblique muscle overaction
title_full	Histopathological and electron microscopic study for different grades of inferior oblique muscle overaction
title_fullStr	Histopathological and electron microscopic study for different grades of inferior oblique muscle overaction
title_full_unstemmed	Histopathological and electron microscopic study for different grades of inferior oblique muscle overaction
title_sort	histopathological and electron microscopic study for different grades of inferior oblique muscle overaction
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/a1e9ba9cf3fd461fb55c7d1a95535ed2
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Histopathological and electron microscopic study for different grades of inferior oblique muscle overaction

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