Impaired immune surveillance accelerates accumulation of senescent cells and aging

Senescent cells accumulate with aging contributing to age-related disease and the role of the immune system in removing senescent cells is not completely understood. Here, the authors show that perforin deficient mice accumulate more senescent cells and have a shorter lifespan, and that this phenoty...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yossi Ovadya, Tomer Landsberger, Hanna Leins, Ezra Vadai, Hilah Gal, Anat Biran, Reut Yosef, Adi Sagiv, Amit Agrawal, Alon Shapira, Joseph Windheim, Michael Tsoory, Reinhold Schirmbeck, Ido Amit, Hartmut Geiger, Valery Krizhanovsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a1ec80e65b354c269b44d215e404c1cc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a1ec80e65b354c269b44d215e404c1cc
record_format	dspace
spelling	oai:doaj.org-article:a1ec80e65b354c269b44d215e404c1cc2021-12-02T14:41:28ZImpaired immune surveillance accelerates accumulation of senescent cells and aging10.1038/s41467-018-07825-32041-1723https://doaj.org/article/a1ec80e65b354c269b44d215e404c1cc2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07825-3https://doaj.org/toc/2041-1723Senescent cells accumulate with aging contributing to age-related disease and the role of the immune system in removing senescent cells is not completely understood. Here, the authors show that perforin deficient mice accumulate more senescent cells and have a shorter lifespan, and that this phenotype can be reversed with administration of a senolytic drug.Yossi OvadyaTomer LandsbergerHanna LeinsEzra VadaiHilah GalAnat BiranReut YosefAdi SagivAmit AgrawalAlon ShapiraJoseph WindheimMichael TsooryReinhold SchirmbeckIdo AmitHartmut GeigerValery KrizhanovskyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yossi Ovadya Tomer Landsberger Hanna Leins Ezra Vadai Hilah Gal Anat Biran Reut Yosef Adi Sagiv Amit Agrawal Alon Shapira Joseph Windheim Michael Tsoory Reinhold Schirmbeck Ido Amit Hartmut Geiger Valery Krizhanovsky Impaired immune surveillance accelerates accumulation of senescent cells and aging
description	Senescent cells accumulate with aging contributing to age-related disease and the role of the immune system in removing senescent cells is not completely understood. Here, the authors show that perforin deficient mice accumulate more senescent cells and have a shorter lifespan, and that this phenotype can be reversed with administration of a senolytic drug.
format	article
author	Yossi Ovadya Tomer Landsberger Hanna Leins Ezra Vadai Hilah Gal Anat Biran Reut Yosef Adi Sagiv Amit Agrawal Alon Shapira Joseph Windheim Michael Tsoory Reinhold Schirmbeck Ido Amit Hartmut Geiger Valery Krizhanovsky
author_facet	Yossi Ovadya Tomer Landsberger Hanna Leins Ezra Vadai Hilah Gal Anat Biran Reut Yosef Adi Sagiv Amit Agrawal Alon Shapira Joseph Windheim Michael Tsoory Reinhold Schirmbeck Ido Amit Hartmut Geiger Valery Krizhanovsky
author_sort	Yossi Ovadya
title	Impaired immune surveillance accelerates accumulation of senescent cells and aging
title_short	Impaired immune surveillance accelerates accumulation of senescent cells and aging
title_full	Impaired immune surveillance accelerates accumulation of senescent cells and aging
title_fullStr	Impaired immune surveillance accelerates accumulation of senescent cells and aging
title_full_unstemmed	Impaired immune surveillance accelerates accumulation of senescent cells and aging
title_sort	impaired immune surveillance accelerates accumulation of senescent cells and aging
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a1ec80e65b354c269b44d215e404c1cc
work_keys_str_mv	AT yossiovadya impairedimmunesurveillanceacceleratesaccumulationofsenescentcellsandaging AT tomerlandsberger impairedimmunesurveillanceacceleratesaccumulationofsenescentcellsandaging AT hannaleins impairedimmunesurveillanceacceleratesaccumulationofsenescentcellsandaging AT ezravadai impairedimmunesurveillanceacceleratesaccumulationofsenescentcellsandaging AT hilahgal impairedimmunesurveillanceacceleratesaccumulationofsenescentcellsandaging AT anatbiran impairedimmunesurveillanceacceleratesaccumulationofsenescentcellsandaging AT reutyosef impairedimmunesurveillanceacceleratesaccumulationofsenescentcellsandaging AT adisagiv impairedimmunesurveillanceacceleratesaccumulationofsenescentcellsandaging AT amitagrawal impairedimmunesurveillanceacceleratesaccumulationofsenescentcellsandaging AT alonshapira impairedimmunesurveillanceacceleratesaccumulationofsenescentcellsandaging AT josephwindheim impairedimmunesurveillanceacceleratesaccumulationofsenescentcellsandaging AT michaeltsoory impairedimmunesurveillanceacceleratesaccumulationofsenescentcellsandaging AT reinholdschirmbeck impairedimmunesurveillanceacceleratesaccumulationofsenescentcellsandaging AT idoamit impairedimmunesurveillanceacceleratesaccumulationofsenescentcellsandaging AT hartmutgeiger impairedimmunesurveillanceacceleratesaccumulationofsenescentcellsandaging AT valerykrizhanovsky impairedimmunesurveillanceacceleratesaccumulationofsenescentcellsandaging
_version_	1718389887688769536

Impaired immune surveillance accelerates accumulation of senescent cells and aging

Ejemplares similares