Impaired immune surveillance accelerates accumulation of senescent cells and aging

Senescent cells accumulate with aging contributing to age-related disease and the role of the immune system in removing senescent cells is not completely understood. Here, the authors show that perforin deficient mice accumulate more senescent cells and have a shorter lifespan, and that this phenoty...

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Autores principales: Yossi Ovadya, Tomer Landsberger, Hanna Leins, Ezra Vadai, Hilah Gal, Anat Biran, Reut Yosef, Adi Sagiv, Amit Agrawal, Alon Shapira, Joseph Windheim, Michael Tsoory, Reinhold Schirmbeck, Ido Amit, Hartmut Geiger, Valery Krizhanovsky
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/a1ec80e65b354c269b44d215e404c1cc
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