<italic toggle="yes">Faecalibacterium</italic> Gut Colonization Is Accelerated by Presence of Older Siblings

ABSTRACT Faecalibacterium prausnitzii is a highly abundant human gut microbe in healthy individuals, but it is present at reduced levels in individuals with gastrointestinal inflammatory diseases. It has therefore been suggested to constitute a marker of a healthy gut and is associated with anti-inf...

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Autores principales:	Martin Frederik Laursen, Rikke Pilmann Laursen, Anni Larnkjær, Christian Mølgaard, Kim F. Michaelsen, Hanne Frøkiær, Martin Iain Bahl, Tine Rask Licht
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	Faecalibacterium infancy siblings Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a1ef8e983fc44862ad4df2a3fef045c3
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spelling	oai:doaj.org-article:a1ef8e983fc44862ad4df2a3fef045c32021-11-15T15:21:53Z<italic toggle="yes">Faecalibacterium</italic> Gut Colonization Is Accelerated by Presence of Older Siblings10.1128/mSphere.00448-172379-5042https://doaj.org/article/a1ef8e983fc44862ad4df2a3fef045c32017-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00448-17https://doaj.org/toc/2379-5042ABSTRACT Faecalibacterium prausnitzii is a highly abundant human gut microbe in healthy individuals, but it is present at reduced levels in individuals with gastrointestinal inflammatory diseases. It has therefore been suggested to constitute a marker of a healthy gut and is associated with anti-inflammatory properties. However, factors affecting the colonization of F. prausnitzii in the human gut during early life are very poorly understood. By analysis of 16S rRNA amplicon sequencing data from three separate infant study populations, we determined the colonization dynamics of Faecalibacterium and factors affecting its establishment in the gut. We found that in particular, the presence of older siblings was consistently associated with Faecalibacterium gut colonization during late infancy and conclude that acquisition of Faecalibacterium is very likely to be accelerated through transfer between siblings. IMPORTANCE Faecalibacterium prausnitzii has been suggested to constitute a key marker of a healthy gut, yet the factors shaping the colonization of this highly oxygen-sensitive, non-spore-forming species in the intestinal environment remain poorly understood. Here, we provide evidence from three separate infant study populations that F. prausnitzii colonization in the gut happens during late infancy and is affected by the number of older siblings in the family. We conclude that Faecalibacterium acquisition is highly likely to be accelerated by contact between siblings. Bearing in mind the immunoregulatory properties of F. prausnitzii and the well-established protective effects against allergic disorders related to the presence of older siblings, early colonization of this species may have profound consequences for child health.Martin Frederik LaursenRikke Pilmann LaursenAnni LarnkjærChristian MølgaardKim F. MichaelsenHanne FrøkiærMartin Iain BahlTine Rask LichtAmerican Society for MicrobiologyarticleFaecalibacteriuminfancysiblingsMicrobiologyQR1-502ENmSphere, Vol 2, Iss 6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Faecalibacterium infancy siblings Microbiology QR1-502
spellingShingle	Faecalibacterium infancy siblings Microbiology QR1-502 Martin Frederik Laursen Rikke Pilmann Laursen Anni Larnkjær Christian Mølgaard Kim F. Michaelsen Hanne Frøkiær Martin Iain Bahl Tine Rask Licht <italic toggle="yes">Faecalibacterium</italic> Gut Colonization Is Accelerated by Presence of Older Siblings
description	ABSTRACT Faecalibacterium prausnitzii is a highly abundant human gut microbe in healthy individuals, but it is present at reduced levels in individuals with gastrointestinal inflammatory diseases. It has therefore been suggested to constitute a marker of a healthy gut and is associated with anti-inflammatory properties. However, factors affecting the colonization of F. prausnitzii in the human gut during early life are very poorly understood. By analysis of 16S rRNA amplicon sequencing data from three separate infant study populations, we determined the colonization dynamics of Faecalibacterium and factors affecting its establishment in the gut. We found that in particular, the presence of older siblings was consistently associated with Faecalibacterium gut colonization during late infancy and conclude that acquisition of Faecalibacterium is very likely to be accelerated through transfer between siblings. IMPORTANCE Faecalibacterium prausnitzii has been suggested to constitute a key marker of a healthy gut, yet the factors shaping the colonization of this highly oxygen-sensitive, non-spore-forming species in the intestinal environment remain poorly understood. Here, we provide evidence from three separate infant study populations that F. prausnitzii colonization in the gut happens during late infancy and is affected by the number of older siblings in the family. We conclude that Faecalibacterium acquisition is highly likely to be accelerated by contact between siblings. Bearing in mind the immunoregulatory properties of F. prausnitzii and the well-established protective effects against allergic disorders related to the presence of older siblings, early colonization of this species may have profound consequences for child health.
format	article
author	Martin Frederik Laursen Rikke Pilmann Laursen Anni Larnkjær Christian Mølgaard Kim F. Michaelsen Hanne Frøkiær Martin Iain Bahl Tine Rask Licht
author_facet	Martin Frederik Laursen Rikke Pilmann Laursen Anni Larnkjær Christian Mølgaard Kim F. Michaelsen Hanne Frøkiær Martin Iain Bahl Tine Rask Licht
author_sort	Martin Frederik Laursen
title	<italic toggle="yes">Faecalibacterium</italic> Gut Colonization Is Accelerated by Presence of Older Siblings
title_short	<italic toggle="yes">Faecalibacterium</italic> Gut Colonization Is Accelerated by Presence of Older Siblings
title_full	<italic toggle="yes">Faecalibacterium</italic> Gut Colonization Is Accelerated by Presence of Older Siblings
title_fullStr	<italic toggle="yes">Faecalibacterium</italic> Gut Colonization Is Accelerated by Presence of Older Siblings
title_full_unstemmed	<italic toggle="yes">Faecalibacterium</italic> Gut Colonization Is Accelerated by Presence of Older Siblings
title_sort	<italic toggle="yes">faecalibacterium</italic> gut colonization is accelerated by presence of older siblings
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/a1ef8e983fc44862ad4df2a3fef045c3
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<italic toggle="yes">Faecalibacterium</italic> Gut Colonization Is Accelerated by Presence of Older Siblings

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