Coronavirus disease 2019 and the gut–lung axis

ABSTRACT: Gastrointestinal and respiratory tract diseases often occur together. There are many overlapping pathologies, leading to the concept of the ‘gut–lung axis’ in which stimulation on one side triggers a response on the other side. This axis appears to be implicated in infections involving sev...

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Autores principales:	Dan Zhou, Qiu Wang, Hanmin Liu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Coronavirus disease 2019 Gut–lung axis Microbiota Dysbiosis Immunity Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/a1f30e1aa73642a88400e0f8be7b6b4e
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spelling	oai:doaj.org-article:a1f30e1aa73642a88400e0f8be7b6b4e2021-11-14T04:31:13ZCoronavirus disease 2019 and the gut–lung axis1201-971210.1016/j.ijid.2021.09.013https://doaj.org/article/a1f30e1aa73642a88400e0f8be7b6b4e2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221007220https://doaj.org/toc/1201-9712ABSTRACT: Gastrointestinal and respiratory tract diseases often occur together. There are many overlapping pathologies, leading to the concept of the ‘gut–lung axis’ in which stimulation on one side triggers a response on the other side. This axis appears to be implicated in infections involving severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which has triggered the global coronavirus disease 2019 (COVID-19) pandemic, in which respiratory symptoms of fever, cough and dyspnoea often occur together with gastrointestinal symptoms such as nausea, vomiting, abdominal pain and diarrhoea. Besides the gut–lung axis, it should be noted that the gut participates in numerous axes which may affect lung function, and consequently the severity of COVID-19, through several pathways. This article focuses on the latest evidence and the mechanisms that drive the operation of the gut–lung axis, and discusses the interaction between the gut–lung axis and its possible involvement in COVID-19 from the perspective of microbiota, microbiota metabolites, microbial dysbiosis, common mucosal immunity and angiotensin-converting enzyme II, raising hypotheses and providing methods to guide future research on this new disease and its treatments.Dan ZhouQiu WangHanmin LiuElsevierarticleCoronavirus disease 2019Gut–lung axisMicrobiotaDysbiosisImmunityInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 113, Iss , Pp 300-307 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Coronavirus disease 2019 Gut–lung axis Microbiota Dysbiosis Immunity Infectious and parasitic diseases RC109-216
spellingShingle	Coronavirus disease 2019 Gut–lung axis Microbiota Dysbiosis Immunity Infectious and parasitic diseases RC109-216 Dan Zhou Qiu Wang Hanmin Liu Coronavirus disease 2019 and the gut–lung axis
description	ABSTRACT: Gastrointestinal and respiratory tract diseases often occur together. There are many overlapping pathologies, leading to the concept of the ‘gut–lung axis’ in which stimulation on one side triggers a response on the other side. This axis appears to be implicated in infections involving severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which has triggered the global coronavirus disease 2019 (COVID-19) pandemic, in which respiratory symptoms of fever, cough and dyspnoea often occur together with gastrointestinal symptoms such as nausea, vomiting, abdominal pain and diarrhoea. Besides the gut–lung axis, it should be noted that the gut participates in numerous axes which may affect lung function, and consequently the severity of COVID-19, through several pathways. This article focuses on the latest evidence and the mechanisms that drive the operation of the gut–lung axis, and discusses the interaction between the gut–lung axis and its possible involvement in COVID-19 from the perspective of microbiota, microbiota metabolites, microbial dysbiosis, common mucosal immunity and angiotensin-converting enzyme II, raising hypotheses and providing methods to guide future research on this new disease and its treatments.
format	article
author	Dan Zhou Qiu Wang Hanmin Liu
author_facet	Dan Zhou Qiu Wang Hanmin Liu
author_sort	Dan Zhou
title	Coronavirus disease 2019 and the gut–lung axis
title_short	Coronavirus disease 2019 and the gut–lung axis
title_full	Coronavirus disease 2019 and the gut–lung axis
title_fullStr	Coronavirus disease 2019 and the gut–lung axis
title_full_unstemmed	Coronavirus disease 2019 and the gut–lung axis
title_sort	coronavirus disease 2019 and the gut–lung axis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/a1f30e1aa73642a88400e0f8be7b6b4e
work_keys_str_mv	AT danzhou coronavirusdisease2019andthegutlungaxis AT qiuwang coronavirusdisease2019andthegutlungaxis AT hanminliu coronavirusdisease2019andthegutlungaxis
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Coronavirus disease 2019 and the gut–lung axis

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