Quantification of purified endogenous miRNAs with high sensitivity and specificity

Quantification of purified endogenous miRNAs with high sensitivity and specificity

MicroRNAs are potentially powerful biomarkers, though clinical use requires rapid and reliable profiling. Here the authors report amplification-free multicolour single-molecule imaging with single base mismatch sensitivity.

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Main Authors: Soochul Shin, Yoonseok Jung, Heesoo Uhm, Minseok Song, Soomin Son, Jiyoung Goo, Cherlhyun Jeong, Ji-Joon Song, V. Narry Kim, Sungchul Hohng
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
Q
Online Access:https://doaj.org/article/a1f97de236b54183ad3bf6dbebd4a004
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spelling oai:doaj.org-article:a1f97de236b54183ad3bf6dbebd4a0042021-12-02T16:56:35ZQuantification of purified endogenous miRNAs with high sensitivity and specificity10.1038/s41467-020-19865-92041-1723https://doaj.org/article/a1f97de236b54183ad3bf6dbebd4a0042020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19865-9https://doaj.org/toc/2041-1723MicroRNAs are potentially powerful biomarkers, though clinical use requires rapid and reliable profiling. Here the authors report amplification-free multicolour single-molecule imaging with single base mismatch sensitivity.Soochul ShinYoonseok JungHeesoo UhmMinseok SongSoomin SonJiyoung GooCherlhyun JeongJi-Joon SongV. Narry KimSungchul HohngNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Soochul Shin
Yoonseok Jung
Heesoo Uhm
Minseok Song
Soomin Son
Jiyoung Goo
Cherlhyun Jeong
Ji-Joon Song
V. Narry Kim
Sungchul Hohng
Quantification of purified endogenous miRNAs with high sensitivity and specificity
description MicroRNAs are potentially powerful biomarkers, though clinical use requires rapid and reliable profiling. Here the authors report amplification-free multicolour single-molecule imaging with single base mismatch sensitivity.
format article
author Soochul Shin
Yoonseok Jung
Heesoo Uhm
Minseok Song
Soomin Son
Jiyoung Goo
Cherlhyun Jeong
Ji-Joon Song
V. Narry Kim
Sungchul Hohng
author_facet Soochul Shin
Yoonseok Jung
Heesoo Uhm
Minseok Song
Soomin Son
Jiyoung Goo
Cherlhyun Jeong
Ji-Joon Song
V. Narry Kim
Sungchul Hohng
author_sort Soochul Shin
title Quantification of purified endogenous miRNAs with high sensitivity and specificity
title_short Quantification of purified endogenous miRNAs with high sensitivity and specificity
title_full Quantification of purified endogenous miRNAs with high sensitivity and specificity
title_fullStr Quantification of purified endogenous miRNAs with high sensitivity and specificity
title_full_unstemmed Quantification of purified endogenous miRNAs with high sensitivity and specificity
title_sort quantification of purified endogenous mirnas with high sensitivity and specificity
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/a1f97de236b54183ad3bf6dbebd4a004
work_keys_str_mv AT soochulshin quantificationofpurifiedendogenousmirnaswithhighsensitivityandspecificity
AT yoonseokjung quantificationofpurifiedendogenousmirnaswithhighsensitivityandspecificity
AT heesoouhm quantificationofpurifiedendogenousmirnaswithhighsensitivityandspecificity
AT minseoksong quantificationofpurifiedendogenousmirnaswithhighsensitivityandspecificity
AT soominson quantificationofpurifiedendogenousmirnaswithhighsensitivityandspecificity
AT jiyounggoo quantificationofpurifiedendogenousmirnaswithhighsensitivityandspecificity
AT cherlhyunjeong quantificationofpurifiedendogenousmirnaswithhighsensitivityandspecificity
AT jijoonsong quantificationofpurifiedendogenousmirnaswithhighsensitivityandspecificity
AT vnarrykim quantificationofpurifiedendogenousmirnaswithhighsensitivityandspecificity
AT sungchulhohng quantificationofpurifiedendogenousmirnaswithhighsensitivityandspecificity
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