Varied-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices

Abstract Medical device-associated infections are a serious medical threat, particularly for patients with impaired mobility and/or advanced age. Despite a variety of antimicrobial coatings for medical devices being explored to date, only a limited number have been introduced for clinical use. Resea...

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Autores principales:	Ewelina Piktel, Łukasz Suprewicz, Joanna Depciuch, Sylwia Chmielewska, Karol Skłodowski, Tamara Daniluk, Grzegorz Król, Paulina Kołat-Brodecka, Piotr Bijak, Anna Pajor-Świerzy, Krzysztof Fiedoruk, Magdalena Parlinska-Wojtan, Robert Bucki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a1fc34a899dd4f41bfe1b07fd5fff3c4
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spelling	oai:doaj.org-article:a1fc34a899dd4f41bfe1b07fd5fff3c42021-12-02T17:24:22ZVaried-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices10.1038/s41598-021-91847-32045-2322https://doaj.org/article/a1fc34a899dd4f41bfe1b07fd5fff3c42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91847-3https://doaj.org/toc/2045-2322Abstract Medical device-associated infections are a serious medical threat, particularly for patients with impaired mobility and/or advanced age. Despite a variety of antimicrobial coatings for medical devices being explored to date, only a limited number have been introduced for clinical use. Research into new bactericidal agents with the ability to eradicate pathogens, limit biofilm formation, and exhibit satisfactory biocompatibility, is therefore necessary and urgent. In this study, a series of varied-morphology gold nanoparticles in shapes of rods, peanuts, stars and spherical-like, porous ones with potent antibacterial activity were synthesized and thoroughly tested against spectrum of Candida albicans, Pseudomonas aeruginosa, Staphylococcus aureus clinical strains, as well as spectrum of uropathogenic Escherichia coli isolates. The optimization of gold nanoparticles synthesis allowed to develop nanomaterials, which are proved to be significantly more potent against tested microbes compared with the gold nanoformulations reported to date. Notably, their antimicrobial spectrum includes strains with different drug resistance mechanisms. Facile and cost-efficient synthesis of gold nanoparticles, remarkable bactericidal efficiency at nanogram doses, and low toxicity, underline their potential for development as a new coatings, as indicated by the example of urological catheters. The presented research fills a gap in microbial studies of non-spherical gold nanoparticles for the development of antimicrobial coatings targeting multidrug-resistant pathogens responsible for device-associated nosocomial infections.Ewelina PiktelŁukasz SuprewiczJoanna DepciuchSylwia ChmielewskaKarol SkłodowskiTamara DanilukGrzegorz KrólPaulina Kołat-BrodeckaPiotr BijakAnna Pajor-ŚwierzyKrzysztof FiedorukMagdalena Parlinska-WojtanRobert BuckiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ewelina Piktel Łukasz Suprewicz Joanna Depciuch Sylwia Chmielewska Karol Skłodowski Tamara Daniluk Grzegorz Król Paulina Kołat-Brodecka Piotr Bijak Anna Pajor-Świerzy Krzysztof Fiedoruk Magdalena Parlinska-Wojtan Robert Bucki Varied-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices
description	Abstract Medical device-associated infections are a serious medical threat, particularly for patients with impaired mobility and/or advanced age. Despite a variety of antimicrobial coatings for medical devices being explored to date, only a limited number have been introduced for clinical use. Research into new bactericidal agents with the ability to eradicate pathogens, limit biofilm formation, and exhibit satisfactory biocompatibility, is therefore necessary and urgent. In this study, a series of varied-morphology gold nanoparticles in shapes of rods, peanuts, stars and spherical-like, porous ones with potent antibacterial activity were synthesized and thoroughly tested against spectrum of Candida albicans, Pseudomonas aeruginosa, Staphylococcus aureus clinical strains, as well as spectrum of uropathogenic Escherichia coli isolates. The optimization of gold nanoparticles synthesis allowed to develop nanomaterials, which are proved to be significantly more potent against tested microbes compared with the gold nanoformulations reported to date. Notably, their antimicrobial spectrum includes strains with different drug resistance mechanisms. Facile and cost-efficient synthesis of gold nanoparticles, remarkable bactericidal efficiency at nanogram doses, and low toxicity, underline their potential for development as a new coatings, as indicated by the example of urological catheters. The presented research fills a gap in microbial studies of non-spherical gold nanoparticles for the development of antimicrobial coatings targeting multidrug-resistant pathogens responsible for device-associated nosocomial infections.
format	article
author	Ewelina Piktel Łukasz Suprewicz Joanna Depciuch Sylwia Chmielewska Karol Skłodowski Tamara Daniluk Grzegorz Król Paulina Kołat-Brodecka Piotr Bijak Anna Pajor-Świerzy Krzysztof Fiedoruk Magdalena Parlinska-Wojtan Robert Bucki
author_facet	Ewelina Piktel Łukasz Suprewicz Joanna Depciuch Sylwia Chmielewska Karol Skłodowski Tamara Daniluk Grzegorz Król Paulina Kołat-Brodecka Piotr Bijak Anna Pajor-Świerzy Krzysztof Fiedoruk Magdalena Parlinska-Wojtan Robert Bucki
author_sort	Ewelina Piktel
title	Varied-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices
title_short	Varied-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices
title_full	Varied-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices
title_fullStr	Varied-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices
title_full_unstemmed	Varied-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices
title_sort	varied-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a1fc34a899dd4f41bfe1b07fd5fff3c4
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Varied-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices

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