CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status.

CD44 marks stem cell-like cells in a number of tumour types, including colorectal cancer (CRC), while aberrant CD44 expression conveys increased tumourigenic, invasive, and metastatic potential. Previous data indicate that CD44 is a direct target of p53-mediated transcriptional repression in breast...

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Autores principales:	Jurrit Zeilstra, Sander P J Joosten, Louis Vermeulen, Jan Koster, Jan Paul Medema, Rogier Versteeg, Marcel Spaargaren, Steven T Pals
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a2015b6f06404d929df298986c786d52
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spelling	oai:doaj.org-article:a2015b6f06404d929df298986c786d522021-11-18T08:57:44ZCD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status.1932-620310.1371/journal.pone.0072849https://doaj.org/article/a2015b6f06404d929df298986c786d522013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24009708/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203CD44 marks stem cell-like cells in a number of tumour types, including colorectal cancer (CRC), while aberrant CD44 expression conveys increased tumourigenic, invasive, and metastatic potential. Previous data indicate that CD44 is a direct target of p53-mediated transcriptional repression in breast cancer. Since inactivating p53 mutations are frequent genetic events in CRC these could unleash expression of CD44. In the present study, we therefore explored the relation between p53 mutational status and CD44 expression in a cohort of 90 localized primary CRCs and studied the effect of radiation-induced p53 activation on CD44 expression. Interestingly, we observed that, in contrast to breast cancer, loss of function p53 mutations were not associated with elevated CD44 expression in colon cancer. Moreover, DNA-damage induced p53 activation did not result in repression of CD44 expression, neither in colon cancer cells nor in normal intestinal epithelial cells. Our data demonstrate that CD44 expression in normal and malignant intestinal epithelial cells is not regulated by p53, implying that regulation of this potentially important therapeutic target is tissue and cancer-type specific.Jurrit ZeilstraSander P J JoostenLouis VermeulenJan KosterJan Paul MedemaRogier VersteegMarcel SpaargarenSteven T PalsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e72849 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jurrit Zeilstra Sander P J Joosten Louis Vermeulen Jan Koster Jan Paul Medema Rogier Versteeg Marcel Spaargaren Steven T Pals CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status.
description	CD44 marks stem cell-like cells in a number of tumour types, including colorectal cancer (CRC), while aberrant CD44 expression conveys increased tumourigenic, invasive, and metastatic potential. Previous data indicate that CD44 is a direct target of p53-mediated transcriptional repression in breast cancer. Since inactivating p53 mutations are frequent genetic events in CRC these could unleash expression of CD44. In the present study, we therefore explored the relation between p53 mutational status and CD44 expression in a cohort of 90 localized primary CRCs and studied the effect of radiation-induced p53 activation on CD44 expression. Interestingly, we observed that, in contrast to breast cancer, loss of function p53 mutations were not associated with elevated CD44 expression in colon cancer. Moreover, DNA-damage induced p53 activation did not result in repression of CD44 expression, neither in colon cancer cells nor in normal intestinal epithelial cells. Our data demonstrate that CD44 expression in normal and malignant intestinal epithelial cells is not regulated by p53, implying that regulation of this potentially important therapeutic target is tissue and cancer-type specific.
format	article
author	Jurrit Zeilstra Sander P J Joosten Louis Vermeulen Jan Koster Jan Paul Medema Rogier Versteeg Marcel Spaargaren Steven T Pals
author_facet	Jurrit Zeilstra Sander P J Joosten Louis Vermeulen Jan Koster Jan Paul Medema Rogier Versteeg Marcel Spaargaren Steven T Pals
author_sort	Jurrit Zeilstra
title	CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status.
title_short	CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status.
title_full	CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status.
title_fullStr	CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status.
title_full_unstemmed	CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status.
title_sort	cd44 expression in intestinal epithelium and colorectal cancer is independent of p53 status.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/a2015b6f06404d929df298986c786d52
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CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status.

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