Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression

Abstract Linc-ROR have been well-demonstrated to play important roles in cancer progression and angiogenesis. However, the underlying oncogenic mechanism of Linc-ROR in hepatocellular carcinoma is poorly understood. In this study, we demonstrate that Linc-ROR plays an oncogenic role in part through...

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Autores principales:	Chuan Tian, Mubalake Abudoureyimu, Xinrong Lin, Xiaoyuan Chu, Rui Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/a202e052fdef4e218f4dbf8f5fd97f8d
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spelling	oai:doaj.org-article:a202e052fdef4e218f4dbf8f5fd97f8d2021-11-07T12:04:58ZLinc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression10.1038/s41419-021-04303-52041-4889https://doaj.org/article/a202e052fdef4e218f4dbf8f5fd97f8d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41419-021-04303-5https://doaj.org/toc/2041-4889Abstract Linc-ROR have been well-demonstrated to play important roles in cancer progression and angiogenesis. However, the underlying oncogenic mechanism of Linc-ROR in hepatocellular carcinoma is poorly understood. In this study, we demonstrate that Linc-ROR plays an oncogenic role in part through its positive regulation of DEPDC1 expression. Mechanistically, Linc-ROR acts as competing endogenous RNA to stabilize DEPDC1 mRNA and regulates DEPDC1 mRNA stability by binding HNRNPK. Thus, these findings suggest that function of Linc-ROR-mediated DEPDC1 could predispose hepatocellular carcinoma patients to progression and angiogenesis, and may serve as a potential target for anticancer therapies.Chuan TianMubalake AbudoureyimuXinrong LinXiaoyuan ChuRui WangNature Publishing GrouparticleCytologyQH573-671ENCell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Chuan Tian Mubalake Abudoureyimu Xinrong Lin Xiaoyuan Chu Rui Wang Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression
description	Abstract Linc-ROR have been well-demonstrated to play important roles in cancer progression and angiogenesis. However, the underlying oncogenic mechanism of Linc-ROR in hepatocellular carcinoma is poorly understood. In this study, we demonstrate that Linc-ROR plays an oncogenic role in part through its positive regulation of DEPDC1 expression. Mechanistically, Linc-ROR acts as competing endogenous RNA to stabilize DEPDC1 mRNA and regulates DEPDC1 mRNA stability by binding HNRNPK. Thus, these findings suggest that function of Linc-ROR-mediated DEPDC1 could predispose hepatocellular carcinoma patients to progression and angiogenesis, and may serve as a potential target for anticancer therapies.
format	article
author	Chuan Tian Mubalake Abudoureyimu Xinrong Lin Xiaoyuan Chu Rui Wang
author_facet	Chuan Tian Mubalake Abudoureyimu Xinrong Lin Xiaoyuan Chu Rui Wang
author_sort	Chuan Tian
title	Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression
title_short	Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression
title_full	Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression
title_fullStr	Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression
title_full_unstemmed	Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression
title_sort	linc-ror facilitates progression and angiogenesis of hepatocellular carcinoma by modulating depdc1 expression
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/a202e052fdef4e218f4dbf8f5fd97f8d
work_keys_str_mv	AT chuantian lincrorfacilitatesprogressionandangiogenesisofhepatocellularcarcinomabymodulatingdepdc1expression AT mubalakeabudoureyimu lincrorfacilitatesprogressionandangiogenesisofhepatocellularcarcinomabymodulatingdepdc1expression AT xinronglin lincrorfacilitatesprogressionandangiogenesisofhepatocellularcarcinomabymodulatingdepdc1expression AT xiaoyuanchu lincrorfacilitatesprogressionandangiogenesisofhepatocellularcarcinomabymodulatingdepdc1expression AT ruiwang lincrorfacilitatesprogressionandangiogenesisofhepatocellularcarcinomabymodulatingdepdc1expression
_version_	1718443565792624640

Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression

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