Reversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity

We earlier reported the protective effect of Solanum dasyphyllum against cyanide neurotoxicity. In furtherance to this, we investigated the protective effect of S. dasyphyllum against rotenone, a chemical toxin that causes brain-related diseases. Mitochondria fraction obtained from the brain of male...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ilesanmi Omotayo B., Efe Obade, Odewale Temitope T., Atanu Francis O., Adeogun Esther F., Akinmoladun Afolabi C., Olaleye Tolulope M.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2020
Materias:	rotenone mitochondria respiratory enzymes oxidative stress solanum dasyphyllum brain Medicine R
Acceso en línea:	https://doaj.org/article/a2092fd23bfe4614bc216581127cb3bd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a2092fd23bfe4614bc216581127cb3bd
record_format	dspace
spelling	oai:doaj.org-article:a2092fd23bfe4614bc216581127cb3bd2021-12-05T14:11:06ZReversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity2300-667610.2478/cipms-2020-0034https://doaj.org/article/a2092fd23bfe4614bc216581127cb3bd2020-12-01T00:00:00Zhttps://doi.org/10.2478/cipms-2020-0034https://doaj.org/toc/2300-6676We earlier reported the protective effect of Solanum dasyphyllum against cyanide neurotoxicity. In furtherance to this, we investigated the protective effect of S. dasyphyllum against rotenone, a chemical toxin that causes brain-related diseases. Mitochondria fraction obtained from the brain of male Wistar rats was incubated with various solvents (hexane, dichloromethane, ethylacetate, and methanol) extracts of S. dasyphyllum before rotenone exposure. Mitochondria respiratory enzymes (MRE) were evaluated along with markers of oxidative stress. The inhibition of MRE by rotenone was reversed by treatment with various fractions of S. dasyphyllum. The oxidative stress induced by rotenone was also reversed by fractions of S. dasyphyllum. In addition, the ethylacetate fraction of S. dasyphyllum was most potent against rotenone-induced neurotoxicity. In conclusion, S. dasyphyllum is rich in active phytochemicals that can prevent some neurotoxic effects of rotenone exposure. Further study can be done in an in vivo model to substantiate our results.Ilesanmi Omotayo B.Efe ObadeOdewale Temitope T.Atanu Francis O.Adeogun Esther F.Akinmoladun Afolabi C.Olaleye Tolulope M.Sciendoarticlerotenonemitochondria respiratory enzymesoxidative stresssolanum dasyphyllumbrainMedicineRENCurrent Issues in Pharmacy and Medical Sciences, Vol 33, Iss 4, Pp 191-196 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	rotenone mitochondria respiratory enzymes oxidative stress solanum dasyphyllum brain Medicine R
spellingShingle	rotenone mitochondria respiratory enzymes oxidative stress solanum dasyphyllum brain Medicine R Ilesanmi Omotayo B. Efe Obade Odewale Temitope T. Atanu Francis O. Adeogun Esther F. Akinmoladun Afolabi C. Olaleye Tolulope M. Reversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity
description	We earlier reported the protective effect of Solanum dasyphyllum against cyanide neurotoxicity. In furtherance to this, we investigated the protective effect of S. dasyphyllum against rotenone, a chemical toxin that causes brain-related diseases. Mitochondria fraction obtained from the brain of male Wistar rats was incubated with various solvents (hexane, dichloromethane, ethylacetate, and methanol) extracts of S. dasyphyllum before rotenone exposure. Mitochondria respiratory enzymes (MRE) were evaluated along with markers of oxidative stress. The inhibition of MRE by rotenone was reversed by treatment with various fractions of S. dasyphyllum. The oxidative stress induced by rotenone was also reversed by fractions of S. dasyphyllum. In addition, the ethylacetate fraction of S. dasyphyllum was most potent against rotenone-induced neurotoxicity. In conclusion, S. dasyphyllum is rich in active phytochemicals that can prevent some neurotoxic effects of rotenone exposure. Further study can be done in an in vivo model to substantiate our results.
format	article
author	Ilesanmi Omotayo B. Efe Obade Odewale Temitope T. Atanu Francis O. Adeogun Esther F. Akinmoladun Afolabi C. Olaleye Tolulope M.
author_facet	Ilesanmi Omotayo B. Efe Obade Odewale Temitope T. Atanu Francis O. Adeogun Esther F. Akinmoladun Afolabi C. Olaleye Tolulope M.
author_sort	Ilesanmi Omotayo B.
title	Reversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity
title_short	Reversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity
title_full	Reversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity
title_fullStr	Reversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity
title_full_unstemmed	Reversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity
title_sort	reversal effect of solanum dasyphyllum against rotenone-induced neurotoxicity
publisher	Sciendo
publishDate	2020
url	https://doaj.org/article/a2092fd23bfe4614bc216581127cb3bd
work_keys_str_mv	AT ilesanmiomotayob reversaleffectofsolanumdasyphyllumagainstrotenoneinducedneurotoxicity AT efeobade reversaleffectofsolanumdasyphyllumagainstrotenoneinducedneurotoxicity AT odewaletemitopet reversaleffectofsolanumdasyphyllumagainstrotenoneinducedneurotoxicity AT atanufranciso reversaleffectofsolanumdasyphyllumagainstrotenoneinducedneurotoxicity AT adeogunestherf reversaleffectofsolanumdasyphyllumagainstrotenoneinducedneurotoxicity AT akinmoladunafolabic reversaleffectofsolanumdasyphyllumagainstrotenoneinducedneurotoxicity AT olaleyetolulopem reversaleffectofsolanumdasyphyllumagainstrotenoneinducedneurotoxicity
_version_	1718371376560078848

Reversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity

Ejemplares similares