Challenges in the clinical measurement of ocular surface disease in glaucoma patients

Stephen C Pflugfelder1, Christophe Baudouin2,3 1Ophthalmology-Ocular Surface Center, Baylor College of Medicine, Houston, TX, USA; 2Department of Ophthalmology, Quinze-Vingts Hospital, Paris, France; 3Vision Institute, Paris, France Abstract: Ocular surface disease (OSD) is common among glaucoma pat...

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Autores principales:	Pflugfelder SC, Baudouin C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a20ad575dc5b43bd87fb3f4a336cd747
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spelling	oai:doaj.org-article:a20ad575dc5b43bd87fb3f4a336cd7472021-12-02T04:13:27ZChallenges in the clinical measurement of ocular surface disease in glaucoma patients1177-54671177-5483https://doaj.org/article/a20ad575dc5b43bd87fb3f4a336cd7472011-11-01T00:00:00Zhttp://www.dovepress.com/challenges-in-the-clinical-measurement-of-ocular-surface-disease-in-gl-a8578https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Stephen C Pflugfelder1, Christophe Baudouin2,3 1Ophthalmology-Ocular Surface Center, Baylor College of Medicine, Houston, TX, USA; 2Department of Ophthalmology, Quinze-Vingts Hospital, Paris, France; 3Vision Institute, Paris, France Abstract: Ocular surface disease (OSD) is common among glaucoma patients. Clinical assessment of OSD can be challenging. This review focuses on some of the limitations relating to both subjective and objective measures of OSD, including dry eye. A survey of the literature was conducted to identify the caveats associated with different methods of assessing OSD. The effect of preservatives on the ocular surface, with respect to glaucoma patients in particular, was also reviewed. Objective methods for assessing ocular surface health and disease include the Schirmer test, tear break-up time, fluorescein turnover, corneal and conjunctival staining, tear osmolarity, and vital dyes. These measures all have limitations in terms of their ability to grade the severity of OSD. Previous studies using the OSD Index showed a mild-to-moderate correlation to dry eye disease severity. Other scoring systems for dry eye have shown a relationship to patient symptom scores or quality of life. Due to the challenges clinicians face concerning both subjective and objective ocular surface health assessments, discerning clinical improvement in ocular surface disease can be a challenge. Further research is needed in order to optimize existing clinical methods and/or identify alternative techniques for assessing OSD in the glaucoma population. Keywords: dry eye, glaucoma, ocular surface disease, ocular surface disease index, preservatives, tear break-up timePflugfelder SCBaudouin CDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 1575-1583 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Pflugfelder SC Baudouin C Challenges in the clinical measurement of ocular surface disease in glaucoma patients
description	Stephen C Pflugfelder1, Christophe Baudouin2,3 1Ophthalmology-Ocular Surface Center, Baylor College of Medicine, Houston, TX, USA; 2Department of Ophthalmology, Quinze-Vingts Hospital, Paris, France; 3Vision Institute, Paris, France Abstract: Ocular surface disease (OSD) is common among glaucoma patients. Clinical assessment of OSD can be challenging. This review focuses on some of the limitations relating to both subjective and objective measures of OSD, including dry eye. A survey of the literature was conducted to identify the caveats associated with different methods of assessing OSD. The effect of preservatives on the ocular surface, with respect to glaucoma patients in particular, was also reviewed. Objective methods for assessing ocular surface health and disease include the Schirmer test, tear break-up time, fluorescein turnover, corneal and conjunctival staining, tear osmolarity, and vital dyes. These measures all have limitations in terms of their ability to grade the severity of OSD. Previous studies using the OSD Index showed a mild-to-moderate correlation to dry eye disease severity. Other scoring systems for dry eye have shown a relationship to patient symptom scores or quality of life. Due to the challenges clinicians face concerning both subjective and objective ocular surface health assessments, discerning clinical improvement in ocular surface disease can be a challenge. Further research is needed in order to optimize existing clinical methods and/or identify alternative techniques for assessing OSD in the glaucoma population. Keywords: dry eye, glaucoma, ocular surface disease, ocular surface disease index, preservatives, tear break-up time
format	article
author	Pflugfelder SC Baudouin C
author_facet	Pflugfelder SC Baudouin C
author_sort	Pflugfelder SC
title	Challenges in the clinical measurement of ocular surface disease in glaucoma patients
title_short	Challenges in the clinical measurement of ocular surface disease in glaucoma patients
title_full	Challenges in the clinical measurement of ocular surface disease in glaucoma patients
title_fullStr	Challenges in the clinical measurement of ocular surface disease in glaucoma patients
title_full_unstemmed	Challenges in the clinical measurement of ocular surface disease in glaucoma patients
title_sort	challenges in the clinical measurement of ocular surface disease in glaucoma patients
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/a20ad575dc5b43bd87fb3f4a336cd747
work_keys_str_mv	AT pflugfeldersc challengesintheclinicalmeasurementofocularsurfacediseaseinglaucomapatients AT baudouinc challengesintheclinicalmeasurementofocularsurfacediseaseinglaucomapatients
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Challenges in the clinical measurement of ocular surface disease in glaucoma patients

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