An epigenetic gene silencing pathway selectively acting on transgenic DNA in the green alga Chlamydomonas
Strong transgene suppression has been observed in Chlamydomonas reinhardtii, but the underlying mechanism is unknown. Here, the authors identify a sirtuin-type histone deacetylase that selectively acts on transgenic DNA to repress gene expression by assembling a repressive chromatin structure compos...
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| Lenguaje: | EN |
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Nature Portfolio
2020
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| Acceso en línea: | https://doaj.org/article/a20d8d3521784cf38c6e1a4183cbef92 |
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oai:doaj.org-article:a20d8d3521784cf38c6e1a4183cbef922021-12-02T13:24:15ZAn epigenetic gene silencing pathway selectively acting on transgenic DNA in the green alga Chlamydomonas10.1038/s41467-020-19983-42041-1723https://doaj.org/article/a20d8d3521784cf38c6e1a4183cbef922020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19983-4https://doaj.org/toc/2041-1723Strong transgene suppression has been observed in Chlamydomonas reinhardtii, but the underlying mechanism is unknown. Here, the authors identify a sirtuin-type histone deacetylase that selectively acts on transgenic DNA to repress gene expression by assembling a repressive chromatin structure composed of deacetylated histones.Juliane NeupertSean D. GallaherYinghong LuDaniela StrenkertNa’ama SegalRouhollah BarahimipourSorel T. Fitz-GibbonMichael SchrodaSabeeha S. MerchantRalph BockNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Juliane Neupert Sean D. Gallaher Yinghong Lu Daniela Strenkert Na’ama Segal Rouhollah Barahimipour Sorel T. Fitz-Gibbon Michael Schroda Sabeeha S. Merchant Ralph Bock An epigenetic gene silencing pathway selectively acting on transgenic DNA in the green alga Chlamydomonas |
| description |
Strong transgene suppression has been observed in Chlamydomonas reinhardtii, but the underlying mechanism is unknown. Here, the authors identify a sirtuin-type histone deacetylase that selectively acts on transgenic DNA to repress gene expression by assembling a repressive chromatin structure composed of deacetylated histones. |
| format |
article |
| author |
Juliane Neupert Sean D. Gallaher Yinghong Lu Daniela Strenkert Na’ama Segal Rouhollah Barahimipour Sorel T. Fitz-Gibbon Michael Schroda Sabeeha S. Merchant Ralph Bock |
| author_facet |
Juliane Neupert Sean D. Gallaher Yinghong Lu Daniela Strenkert Na’ama Segal Rouhollah Barahimipour Sorel T. Fitz-Gibbon Michael Schroda Sabeeha S. Merchant Ralph Bock |
| author_sort |
Juliane Neupert |
| title |
An epigenetic gene silencing pathway selectively acting on transgenic DNA in the green alga Chlamydomonas |
| title_short |
An epigenetic gene silencing pathway selectively acting on transgenic DNA in the green alga Chlamydomonas |
| title_full |
An epigenetic gene silencing pathway selectively acting on transgenic DNA in the green alga Chlamydomonas |
| title_fullStr |
An epigenetic gene silencing pathway selectively acting on transgenic DNA in the green alga Chlamydomonas |
| title_full_unstemmed |
An epigenetic gene silencing pathway selectively acting on transgenic DNA in the green alga Chlamydomonas |
| title_sort |
epigenetic gene silencing pathway selectively acting on transgenic dna in the green alga chlamydomonas |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/a20d8d3521784cf38c6e1a4183cbef92 |
| work_keys_str_mv |
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