Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties

Abstract Mauritius Island possesses unique plant biodiversity with a potential reservoir of biologically active compounds of pharmacological interest. In the current study, we investigated Mauritius endemic plant families Asteraceae, Ebenaceae, Sapotaceae, and Erythroxylaceae, for anti-cancer proper...

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Autores principales:	Shahin Kauroo, Joyce Govinden-Soulange, V. Mala Ranghoo-Sanmukhiya, Kathryn Miranda, William E. Cotham, Michael D. Walla, Mitzi Nagarkatti, Prakash Nagarkatti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a20f2670b24c4c2f80c972f2b98d1cd7
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spelling	oai:doaj.org-article:a20f2670b24c4c2f80c972f2b98d1cd72021-12-02T10:54:23ZExtracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties10.1038/s41598-021-83461-02045-2322https://doaj.org/article/a20f2670b24c4c2f80c972f2b98d1cd72021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83461-0https://doaj.org/toc/2045-2322Abstract Mauritius Island possesses unique plant biodiversity with a potential reservoir of biologically active compounds of pharmacological interest. In the current study, we investigated Mauritius endemic plant families Asteraceae, Ebenaceae, Sapotaceae, and Erythroxylaceae, for anti-cancer properties on T cell lymphoma and B16F10 Melanoma cells and immunomodulatory properties on primary T and B cells. The cytotoxicity of methanolic plant extracts at 1, 10, 25 µg/ml was determined. The most active plant species were evaluated for their apoptosis-inducing effects. The immunomodulatory properties of the plants were also studied, and preliminary phytochemical screening of selected plants was done by LC–MS analysis. Psiadia lithospermifolia (Lam.) Cordem (Asteraceae) at 25 µg/ml was the most cytotoxic on both EL4 and B16 cells and triggered apoptosis by the death receptor pathway, and at least in part, by the mitochondrial pathway. Most plant species from Asteraceae, Ebenaceae, Erythroxylaceae, and Sapotaceae inhibited the proliferation of activated T and B cells, although some promoted T cell proliferation. LC–MS profile of Asteraceae plants showed the presence of terpenes, terpenoids, fatty acids, and phenolic. Flavonoids and phenolic acid were also detected from Ebenaceae and Sapotaceae plants. Together, our study demonstrated that Mauritius endemic flora exhibit potential anti-cancer and anti-inflammatory properties worthy of further in-depth studies.Shahin KaurooJoyce Govinden-SoulangeV. Mala Ranghoo-SanmukhiyaKathryn MirandaWilliam E. CothamMichael D. WallaMitzi NagarkattiPrakash NagarkattiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shahin Kauroo Joyce Govinden-Soulange V. Mala Ranghoo-Sanmukhiya Kathryn Miranda William E. Cotham Michael D. Walla Mitzi Nagarkatti Prakash Nagarkatti Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties
description	Abstract Mauritius Island possesses unique plant biodiversity with a potential reservoir of biologically active compounds of pharmacological interest. In the current study, we investigated Mauritius endemic plant families Asteraceae, Ebenaceae, Sapotaceae, and Erythroxylaceae, for anti-cancer properties on T cell lymphoma and B16F10 Melanoma cells and immunomodulatory properties on primary T and B cells. The cytotoxicity of methanolic plant extracts at 1, 10, 25 µg/ml was determined. The most active plant species were evaluated for their apoptosis-inducing effects. The immunomodulatory properties of the plants were also studied, and preliminary phytochemical screening of selected plants was done by LC–MS analysis. Psiadia lithospermifolia (Lam.) Cordem (Asteraceae) at 25 µg/ml was the most cytotoxic on both EL4 and B16 cells and triggered apoptosis by the death receptor pathway, and at least in part, by the mitochondrial pathway. Most plant species from Asteraceae, Ebenaceae, Erythroxylaceae, and Sapotaceae inhibited the proliferation of activated T and B cells, although some promoted T cell proliferation. LC–MS profile of Asteraceae plants showed the presence of terpenes, terpenoids, fatty acids, and phenolic. Flavonoids and phenolic acid were also detected from Ebenaceae and Sapotaceae plants. Together, our study demonstrated that Mauritius endemic flora exhibit potential anti-cancer and anti-inflammatory properties worthy of further in-depth studies.
format	article
author	Shahin Kauroo Joyce Govinden-Soulange V. Mala Ranghoo-Sanmukhiya Kathryn Miranda William E. Cotham Michael D. Walla Mitzi Nagarkatti Prakash Nagarkatti
author_facet	Shahin Kauroo Joyce Govinden-Soulange V. Mala Ranghoo-Sanmukhiya Kathryn Miranda William E. Cotham Michael D. Walla Mitzi Nagarkatti Prakash Nagarkatti
author_sort	Shahin Kauroo
title	Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties
title_short	Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties
title_full	Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties
title_fullStr	Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties
title_full_unstemmed	Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties
title_sort	extracts of select endemic plants from the republic of mauritius exhibiting anti-cancer and immunomodulatory properties
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a20f2670b24c4c2f80c972f2b98d1cd7
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Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties

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