Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis

Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis

Dietary extracellular vesicles (EVs) could potentially be absorbed by the intestinal tract of the host and exert multiple phenotypic changes. Here, the authors isolate and characterize EVs from raw and commercial bovine milk and show orally administered EVs to have a context specific role in promoti...

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Autores principales: Monisha Samuel, Pamali Fonseka, Rahul Sanwlani, Lahiru Gangoda, Sing Ho Chee, Shivakumar Keerthikumar, Alex Spurling, Sai V. Chitti, Damien Zanker, Ching-Seng Ang, Ishara Atukorala, Taeyoung Kang, Sanjay Shahi, Akbar L. Marzan, Christina Nedeva, Claire Vennin, Morghan C. Lucas, Lesley Cheng, David Herrmann, Mohashin Pathan, David Chisanga, Sean C. Warren, Kening Zhao, Nidhi Abraham, Sushma Anand, Stephanie Boukouris, Christopher G. Adda, Lanzhou Jiang, Tanmay M. Shekhar, Nikola Baschuk, Christine J. Hawkins, Amelia J. Johnston, Jacqueline Monique Orian, Nicholas J. Hoogenraad, Ivan K. Poon, Andrew F. Hill, Markandeya Jois, Paul Timpson, Belinda S. Parker, Suresh Mathivanan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a210d2d7abd146b99318109f85a7d355
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Sumario:Dietary extracellular vesicles (EVs) could potentially be absorbed by the intestinal tract of the host and exert multiple phenotypic changes. Here, the authors isolate and characterize EVs from raw and commercial bovine milk and show orally administered EVs to have a context specific role in promoting or suppressing primary tumor growth and metastasis in multiple mouse tumor models.

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