Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis
Dietary extracellular vesicles (EVs) could potentially be absorbed by the intestinal tract of the host and exert multiple phenotypic changes. Here, the authors isolate and characterize EVs from raw and commercial bovine milk and show orally administered EVs to have a context specific role in promoti...
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Nature Portfolio
2021
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oai:doaj.org-article:a210d2d7abd146b99318109f85a7d3552021-12-02T18:02:46ZOral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis10.1038/s41467-021-24273-82041-1723https://doaj.org/article/a210d2d7abd146b99318109f85a7d3552021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24273-8https://doaj.org/toc/2041-1723Dietary extracellular vesicles (EVs) could potentially be absorbed by the intestinal tract of the host and exert multiple phenotypic changes. Here, the authors isolate and characterize EVs from raw and commercial bovine milk and show orally administered EVs to have a context specific role in promoting or suppressing primary tumor growth and metastasis in multiple mouse tumor models.Monisha SamuelPamali FonsekaRahul SanwlaniLahiru GangodaSing Ho CheeShivakumar KeerthikumarAlex SpurlingSai V. ChittiDamien ZankerChing-Seng AngIshara AtukoralaTaeyoung KangSanjay ShahiAkbar L. MarzanChristina NedevaClaire VenninMorghan C. LucasLesley ChengDavid HerrmannMohashin PathanDavid ChisangaSean C. WarrenKening ZhaoNidhi AbrahamSushma AnandStephanie BoukourisChristopher G. AddaLanzhou JiangTanmay M. ShekharNikola BaschukChristine J. HawkinsAmelia J. JohnstonJacqueline Monique OrianNicholas J. HoogenraadIvan K. PoonAndrew F. HillMarkandeya JoisPaul TimpsonBelinda S. ParkerSuresh MathivananNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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DOAJ |
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EN |
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Science Q |
| spellingShingle |
Science Q Monisha Samuel Pamali Fonseka Rahul Sanwlani Lahiru Gangoda Sing Ho Chee Shivakumar Keerthikumar Alex Spurling Sai V. Chitti Damien Zanker Ching-Seng Ang Ishara Atukorala Taeyoung Kang Sanjay Shahi Akbar L. Marzan Christina Nedeva Claire Vennin Morghan C. Lucas Lesley Cheng David Herrmann Mohashin Pathan David Chisanga Sean C. Warren Kening Zhao Nidhi Abraham Sushma Anand Stephanie Boukouris Christopher G. Adda Lanzhou Jiang Tanmay M. Shekhar Nikola Baschuk Christine J. Hawkins Amelia J. Johnston Jacqueline Monique Orian Nicholas J. Hoogenraad Ivan K. Poon Andrew F. Hill Markandeya Jois Paul Timpson Belinda S. Parker Suresh Mathivanan Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis |
| description |
Dietary extracellular vesicles (EVs) could potentially be absorbed by the intestinal tract of the host and exert multiple phenotypic changes. Here, the authors isolate and characterize EVs from raw and commercial bovine milk and show orally administered EVs to have a context specific role in promoting or suppressing primary tumor growth and metastasis in multiple mouse tumor models. |
| format |
article |
| author |
Monisha Samuel Pamali Fonseka Rahul Sanwlani Lahiru Gangoda Sing Ho Chee Shivakumar Keerthikumar Alex Spurling Sai V. Chitti Damien Zanker Ching-Seng Ang Ishara Atukorala Taeyoung Kang Sanjay Shahi Akbar L. Marzan Christina Nedeva Claire Vennin Morghan C. Lucas Lesley Cheng David Herrmann Mohashin Pathan David Chisanga Sean C. Warren Kening Zhao Nidhi Abraham Sushma Anand Stephanie Boukouris Christopher G. Adda Lanzhou Jiang Tanmay M. Shekhar Nikola Baschuk Christine J. Hawkins Amelia J. Johnston Jacqueline Monique Orian Nicholas J. Hoogenraad Ivan K. Poon Andrew F. Hill Markandeya Jois Paul Timpson Belinda S. Parker Suresh Mathivanan |
| author_facet |
Monisha Samuel Pamali Fonseka Rahul Sanwlani Lahiru Gangoda Sing Ho Chee Shivakumar Keerthikumar Alex Spurling Sai V. Chitti Damien Zanker Ching-Seng Ang Ishara Atukorala Taeyoung Kang Sanjay Shahi Akbar L. Marzan Christina Nedeva Claire Vennin Morghan C. Lucas Lesley Cheng David Herrmann Mohashin Pathan David Chisanga Sean C. Warren Kening Zhao Nidhi Abraham Sushma Anand Stephanie Boukouris Christopher G. Adda Lanzhou Jiang Tanmay M. Shekhar Nikola Baschuk Christine J. Hawkins Amelia J. Johnston Jacqueline Monique Orian Nicholas J. Hoogenraad Ivan K. Poon Andrew F. Hill Markandeya Jois Paul Timpson Belinda S. Parker Suresh Mathivanan |
| author_sort |
Monisha Samuel |
| title |
Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis |
| title_short |
Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis |
| title_full |
Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis |
| title_fullStr |
Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis |
| title_full_unstemmed |
Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis |
| title_sort |
oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a210d2d7abd146b99318109f85a7d355 |
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