A quasi-integral controller for adaptation of genetic modules to variable ribosome demand

Competition for shared cellular resources often renders genetic circuits poorly predictable. Here the authors design a biomolecular quasi-integral controller that allows gene expression to adapt to variable demand in translation resources.

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Autores principales:	Hsin-Ho Huang, Yili Qian, Domitilla Del Vecchio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a21277718beb4c2d8c7c9d40cb7e1f5f
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spelling	oai:doaj.org-article:a21277718beb4c2d8c7c9d40cb7e1f5f2021-12-02T16:49:54ZA quasi-integral controller for adaptation of genetic modules to variable ribosome demand10.1038/s41467-018-07899-z2041-1723https://doaj.org/article/a21277718beb4c2d8c7c9d40cb7e1f5f2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07899-zhttps://doaj.org/toc/2041-1723Competition for shared cellular resources often renders genetic circuits poorly predictable. Here the authors design a biomolecular quasi-integral controller that allows gene expression to adapt to variable demand in translation resources.Hsin-Ho HuangYili QianDomitilla Del VecchioNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hsin-Ho Huang Yili Qian Domitilla Del Vecchio A quasi-integral controller for adaptation of genetic modules to variable ribosome demand
description	Competition for shared cellular resources often renders genetic circuits poorly predictable. Here the authors design a biomolecular quasi-integral controller that allows gene expression to adapt to variable demand in translation resources.
format	article
author	Hsin-Ho Huang Yili Qian Domitilla Del Vecchio
author_facet	Hsin-Ho Huang Yili Qian Domitilla Del Vecchio
author_sort	Hsin-Ho Huang
title	A quasi-integral controller for adaptation of genetic modules to variable ribosome demand
title_short	A quasi-integral controller for adaptation of genetic modules to variable ribosome demand
title_full	A quasi-integral controller for adaptation of genetic modules to variable ribosome demand
title_fullStr	A quasi-integral controller for adaptation of genetic modules to variable ribosome demand
title_full_unstemmed	A quasi-integral controller for adaptation of genetic modules to variable ribosome demand
title_sort	quasi-integral controller for adaptation of genetic modules to variable ribosome demand
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a21277718beb4c2d8c7c9d40cb7e1f5f
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A quasi-integral controller for adaptation of genetic modules to variable ribosome demand

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