Similar Neural Pathways Control Foraging in Mosquitoes and Worms

ABSTRACT Female Aedes aegypti mosquitoes bite human hosts to obtain a blood meal and, in the process, act as vectors for many disease-causing viruses, including the dengue, chikungunya, yellow fever, and Zika viruses. After a complete meal, the female mosquitoes lose attraction to their hosts for se...

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Autores principales:	Jogender Singh, Alejandro Aballay
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	A. aegypti C. elegans NPR-1 aversion behavior bacterial colonization feeding Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a213854fe508458e953e281d8fdcd349
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spelling	oai:doaj.org-article:a213854fe508458e953e281d8fdcd3492021-11-15T15:55:26ZSimilar Neural Pathways Control Foraging in Mosquitoes and Worms10.1128/mBio.00656-192150-7511https://doaj.org/article/a213854fe508458e953e281d8fdcd3492019-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00656-19https://doaj.org/toc/2150-7511ABSTRACT Female Aedes aegypti mosquitoes bite human hosts to obtain a blood meal and, in the process, act as vectors for many disease-causing viruses, including the dengue, chikungunya, yellow fever, and Zika viruses. After a complete meal, the female mosquitoes lose attraction to their hosts for several days. New research shows that pharmacological activation of neuropeptide Y-like receptor (NPYLR) signaling elicits host aversion in female mosquitoes. This behavior of mosquitoes shows remarkable similarities to a bacterial-aversion behavior of the nematode Caenorhabditis elegans. Feeding on pathogenic bacteria causes bloating of the gut in C. elegans that leads to activation of NPYLR signaling and bacterial aversion. Several studies suggest that this newly discovered mechanism underlying foraging may be conserved across a large number of species. A better understanding of the regulation of NPYLR signaling pathways could provide molecular targets for the control of eating behaviors in different animals, including human-disease vectors.Jogender SinghAlejandro AballayAmerican Society for MicrobiologyarticleA. aegyptiC. elegansNPR-1aversion behaviorbacterial colonizationfeedingMicrobiologyQR1-502ENmBio, Vol 10, Iss 2 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	A. aegypti C. elegans NPR-1 aversion behavior bacterial colonization feeding Microbiology QR1-502
spellingShingle	A. aegypti C. elegans NPR-1 aversion behavior bacterial colonization feeding Microbiology QR1-502 Jogender Singh Alejandro Aballay Similar Neural Pathways Control Foraging in Mosquitoes and Worms
description	ABSTRACT Female Aedes aegypti mosquitoes bite human hosts to obtain a blood meal and, in the process, act as vectors for many disease-causing viruses, including the dengue, chikungunya, yellow fever, and Zika viruses. After a complete meal, the female mosquitoes lose attraction to their hosts for several days. New research shows that pharmacological activation of neuropeptide Y-like receptor (NPYLR) signaling elicits host aversion in female mosquitoes. This behavior of mosquitoes shows remarkable similarities to a bacterial-aversion behavior of the nematode Caenorhabditis elegans. Feeding on pathogenic bacteria causes bloating of the gut in C. elegans that leads to activation of NPYLR signaling and bacterial aversion. Several studies suggest that this newly discovered mechanism underlying foraging may be conserved across a large number of species. A better understanding of the regulation of NPYLR signaling pathways could provide molecular targets for the control of eating behaviors in different animals, including human-disease vectors.
format	article
author	Jogender Singh Alejandro Aballay
author_facet	Jogender Singh Alejandro Aballay
author_sort	Jogender Singh
title	Similar Neural Pathways Control Foraging in Mosquitoes and Worms
title_short	Similar Neural Pathways Control Foraging in Mosquitoes and Worms
title_full	Similar Neural Pathways Control Foraging in Mosquitoes and Worms
title_fullStr	Similar Neural Pathways Control Foraging in Mosquitoes and Worms
title_full_unstemmed	Similar Neural Pathways Control Foraging in Mosquitoes and Worms
title_sort	similar neural pathways control foraging in mosquitoes and worms
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/a213854fe508458e953e281d8fdcd349
work_keys_str_mv	AT jogendersingh similarneuralpathwayscontrolforaginginmosquitoesandworms AT alejandroaballay similarneuralpathwayscontrolforaginginmosquitoesandworms
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Similar Neural Pathways Control Foraging in Mosquitoes and Worms

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