Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma

Whether the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have a different role in glioblastoma progression and resistance to therapies is currently unclear. Here, the authors, by long-term tracking of individual glioma, demonstrate that both nich...

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Autores principales:	Erik Jung, Matthias Osswald, Miriam Ratliff, Helin Dogan, Ruifan Xie, Sophie Weil, Dirk C. Hoffmann, Felix T. Kurz, Tobias Kessler, Sabine Heiland, Andreas von Deimling, Felix Sahm, Wolfgang Wick, Frank Winkler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a219a87b2e5c41669d28b24deca0d0b9
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spelling	oai:doaj.org-article:a219a87b2e5c41669d28b24deca0d0b92021-12-02T12:09:44ZTumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma10.1038/s41467-021-21117-32041-1723https://doaj.org/article/a219a87b2e5c41669d28b24deca0d0b92021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21117-3https://doaj.org/toc/2041-1723Whether the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have a different role in glioblastoma progression and resistance to therapies is currently unclear. Here, the authors, by long-term tracking of individual glioma, demonstrate that both niches can partially compensate for each other and that glioma cells localized in both niches are resistant to radio- and chemotherapy.Erik JungMatthias OsswaldMiriam RatliffHelin DoganRuifan XieSophie WeilDirk C. HoffmannFelix T. KurzTobias KesslerSabine HeilandAndreas von DeimlingFelix SahmWolfgang WickFrank WinklerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erik Jung Matthias Osswald Miriam Ratliff Helin Dogan Ruifan Xie Sophie Weil Dirk C. Hoffmann Felix T. Kurz Tobias Kessler Sabine Heiland Andreas von Deimling Felix Sahm Wolfgang Wick Frank Winkler Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma
description	Whether the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have a different role in glioblastoma progression and resistance to therapies is currently unclear. Here, the authors, by long-term tracking of individual glioma, demonstrate that both niches can partially compensate for each other and that glioma cells localized in both niches are resistant to radio- and chemotherapy.
format	article
author	Erik Jung Matthias Osswald Miriam Ratliff Helin Dogan Ruifan Xie Sophie Weil Dirk C. Hoffmann Felix T. Kurz Tobias Kessler Sabine Heiland Andreas von Deimling Felix Sahm Wolfgang Wick Frank Winkler
author_facet	Erik Jung Matthias Osswald Miriam Ratliff Helin Dogan Ruifan Xie Sophie Weil Dirk C. Hoffmann Felix T. Kurz Tobias Kessler Sabine Heiland Andreas von Deimling Felix Sahm Wolfgang Wick Frank Winkler
author_sort	Erik Jung
title	Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma
title_short	Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma
title_full	Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma
title_fullStr	Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma
title_full_unstemmed	Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma
title_sort	tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a219a87b2e5c41669d28b24deca0d0b9
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Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma

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