Unravelling the structural complexity of glycolipids with cryogenic infrared spectroscopy

Glycolipids are glycoconjugates with important biological functions, but techniques for their analysis are deficient. Here, the authors report the use of cryogenic gas-phase infrared spectroscopy to investigate isomerism in a set of immunologically relevant glycolipids, and show that their structura...

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Autores principales: Carla Kirschbaum, Kim Greis, Eike Mucha, Lisa Kain, Shenglou Deng, Andreas Zappe, Sandy Gewinner, Wieland Schöllkopf, Gert von Helden, Gerard Meijer, Paul B. Savage, Mateusz Marianski, Luc Teyton, Kevin Pagel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a21a464c5dbd442ba4a70c62e515703b
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Sumario:Glycolipids are glycoconjugates with important biological functions, but techniques for their analysis are deficient. Here, the authors report the use of cryogenic gas-phase infrared spectroscopy to investigate isomerism in a set of immunologically relevant glycolipids, and show that their structural features can be accurately resolved based on a narrow spectral fingerprint region.