Severity of non-alcoholic steatohepatitis is not linked to testosterone concentration in patients with type 2 diabetes.

<h4>Background</h4>Hypogonadism is reported to occur in non-alcoholic fatty liver disease (NAFLD), but earlier studies used low-sensitivity diagnostic techniques (CT, ultrasound), for NAFLD diagnosis. We hypothesized that if hypogonadism was due to NAFLD, and not solely attributable to u...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kristin Alexandra Dayton, Fernando Bril, Diana Barb, Jinping Lai, Srilaxmi Kalavalapalli, Kenneth Cusi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a21b9e6913004e2a81f3a4e994607c9a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a21b9e6913004e2a81f3a4e994607c9a
record_format	dspace
spelling	oai:doaj.org-article:a21b9e6913004e2a81f3a4e994607c9a2021-12-02T20:05:22ZSeverity of non-alcoholic steatohepatitis is not linked to testosterone concentration in patients with type 2 diabetes.1932-620310.1371/journal.pone.0251449https://doaj.org/article/a21b9e6913004e2a81f3a4e994607c9a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251449https://doaj.org/toc/1932-6203<h4>Background</h4>Hypogonadism is reported to occur in non-alcoholic fatty liver disease (NAFLD), but earlier studies used low-sensitivity diagnostic techniques (CT, ultrasound), for NAFLD diagnosis. We hypothesized that if hypogonadism was due to NAFLD, and not solely attributable to underlying obesity/diabetes, it would be more severe in the presence of steatohepatitis (NASH). To examine the influence of liver disease on testosterone in males with type 2 diabetes mellitus (T2DM), we used gold-standard liver imaging with MR-spectroscopy (1H-MRS), and performed liver biopsies to grade/stage the NAFLD.<h4>Methods</h4>In this cross-sectional study, we measured in 175 males with T2DM total and free testosterone, markers of insulin resistance, and intrahepatic triglyceride content (IHTG) by 1H-MRS. Those with NAFLD on imaging underwent a liver biopsy.<h4>Results</h4>Total testosterone was higher in the group without NAFLD ("No-NAFLD"; n = 48) compared to isolated steatosis (IS; n = 62) or NASH (n = 65) (385 ± 116 vs. 339 ± 143 vs. 335 ± 127 ng/ml, ptrend 0.03). Testosterone was also lower in obese vs. non-obese subjects in both the No-NAFLD and IS groups (p = 0.06 and p = 0.11, respectively), but not in obese vs. non-obese patients with NASH (p = 0.81). IHTG was independently associated with total testosterone (ß = -4.8, p = 0.004). None of the liver histology characteristics were associated with lower testosterone.<h4>Conclusions</h4>NAFLD is linked to lower total testosterone in patients with T2DM, but likely given a common soil of insulin resistance/obesity and not from the severity of liver necroinflammation or fibrosis. Nevertheless, clinicians should consider screening patients with T2DM and NAFLD for hypogonadism.Kristin Alexandra DaytonFernando BrilDiana BarbJinping LaiSrilaxmi KalavalapalliKenneth CusiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0251449 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kristin Alexandra Dayton Fernando Bril Diana Barb Jinping Lai Srilaxmi Kalavalapalli Kenneth Cusi Severity of non-alcoholic steatohepatitis is not linked to testosterone concentration in patients with type 2 diabetes.
description	<h4>Background</h4>Hypogonadism is reported to occur in non-alcoholic fatty liver disease (NAFLD), but earlier studies used low-sensitivity diagnostic techniques (CT, ultrasound), for NAFLD diagnosis. We hypothesized that if hypogonadism was due to NAFLD, and not solely attributable to underlying obesity/diabetes, it would be more severe in the presence of steatohepatitis (NASH). To examine the influence of liver disease on testosterone in males with type 2 diabetes mellitus (T2DM), we used gold-standard liver imaging with MR-spectroscopy (1H-MRS), and performed liver biopsies to grade/stage the NAFLD.<h4>Methods</h4>In this cross-sectional study, we measured in 175 males with T2DM total and free testosterone, markers of insulin resistance, and intrahepatic triglyceride content (IHTG) by 1H-MRS. Those with NAFLD on imaging underwent a liver biopsy.<h4>Results</h4>Total testosterone was higher in the group without NAFLD ("No-NAFLD"; n = 48) compared to isolated steatosis (IS; n = 62) or NASH (n = 65) (385 ± 116 vs. 339 ± 143 vs. 335 ± 127 ng/ml, ptrend 0.03). Testosterone was also lower in obese vs. non-obese subjects in both the No-NAFLD and IS groups (p = 0.06 and p = 0.11, respectively), but not in obese vs. non-obese patients with NASH (p = 0.81). IHTG was independently associated with total testosterone (ß = -4.8, p = 0.004). None of the liver histology characteristics were associated with lower testosterone.<h4>Conclusions</h4>NAFLD is linked to lower total testosterone in patients with T2DM, but likely given a common soil of insulin resistance/obesity and not from the severity of liver necroinflammation or fibrosis. Nevertheless, clinicians should consider screening patients with T2DM and NAFLD for hypogonadism.
format	article
author	Kristin Alexandra Dayton Fernando Bril Diana Barb Jinping Lai Srilaxmi Kalavalapalli Kenneth Cusi
author_facet	Kristin Alexandra Dayton Fernando Bril Diana Barb Jinping Lai Srilaxmi Kalavalapalli Kenneth Cusi
author_sort	Kristin Alexandra Dayton
title	Severity of non-alcoholic steatohepatitis is not linked to testosterone concentration in patients with type 2 diabetes.
title_short	Severity of non-alcoholic steatohepatitis is not linked to testosterone concentration in patients with type 2 diabetes.
title_full	Severity of non-alcoholic steatohepatitis is not linked to testosterone concentration in patients with type 2 diabetes.
title_fullStr	Severity of non-alcoholic steatohepatitis is not linked to testosterone concentration in patients with type 2 diabetes.
title_full_unstemmed	Severity of non-alcoholic steatohepatitis is not linked to testosterone concentration in patients with type 2 diabetes.
title_sort	severity of non-alcoholic steatohepatitis is not linked to testosterone concentration in patients with type 2 diabetes.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a21b9e6913004e2a81f3a4e994607c9a
work_keys_str_mv	AT kristinalexandradayton severityofnonalcoholicsteatohepatitisisnotlinkedtotestosteroneconcentrationinpatientswithtype2diabetes AT fernandobril severityofnonalcoholicsteatohepatitisisnotlinkedtotestosteroneconcentrationinpatientswithtype2diabetes AT dianabarb severityofnonalcoholicsteatohepatitisisnotlinkedtotestosteroneconcentrationinpatientswithtype2diabetes AT jinpinglai severityofnonalcoholicsteatohepatitisisnotlinkedtotestosteroneconcentrationinpatientswithtype2diabetes AT srilaxmikalavalapalli severityofnonalcoholicsteatohepatitisisnotlinkedtotestosteroneconcentrationinpatientswithtype2diabetes AT kennethcusi severityofnonalcoholicsteatohepatitisisnotlinkedtotestosteroneconcentrationinpatientswithtype2diabetes
_version_	1718375499597611008

Severity of non-alcoholic steatohepatitis is not linked to testosterone concentration in patients with type 2 diabetes.

Ejemplares similares