Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia
Leukaemia therapy may benefit from the use of antigens that are less restricted to individual donors. Here the authors engineered T cells with a TCR specific for a CD1c restricted lipid leukaemia antigen and show that they can protect against disease progression in mouse leukaemia xenograft models.
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Nature Portfolio
2021
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oai:doaj.org-article:a21e6ce293244d2e824f24fa9452ea8d2021-12-02T15:07:56ZHuman T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia10.1038/s41467-021-25223-02041-1723https://doaj.org/article/a21e6ce293244d2e824f24fa9452ea8d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25223-0https://doaj.org/toc/2041-1723Leukaemia therapy may benefit from the use of antigens that are less restricted to individual donors. Here the authors engineered T cells with a TCR specific for a CD1c restricted lipid leukaemia antigen and show that they can protect against disease progression in mouse leukaemia xenograft models.Michela ConsonniClaudio GaravagliaAndrea GrilliClaudia de LallaAlessandra MancinoLucia MoriGennaro De LiberoDaniela MontagnaMonica CasucciMarta SerafiniChiara BoniniDaniel HäussingerFabio CiceriMassimo BernardiSara MastaglioSilvio BicciatoPaolo DellabonaGiulia CasoratiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Michela Consonni Claudio Garavaglia Andrea Grilli Claudia de Lalla Alessandra Mancino Lucia Mori Gennaro De Libero Daniela Montagna Monica Casucci Marta Serafini Chiara Bonini Daniel Häussinger Fabio Ciceri Massimo Bernardi Sara Mastaglio Silvio Bicciato Paolo Dellabona Giulia Casorati Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia |
| description |
Leukaemia therapy may benefit from the use of antigens that are less restricted to individual donors. Here the authors engineered T cells with a TCR specific for a CD1c restricted lipid leukaemia antigen and show that they can protect against disease progression in mouse leukaemia xenograft models. |
| format |
article |
| author |
Michela Consonni Claudio Garavaglia Andrea Grilli Claudia de Lalla Alessandra Mancino Lucia Mori Gennaro De Libero Daniela Montagna Monica Casucci Marta Serafini Chiara Bonini Daniel Häussinger Fabio Ciceri Massimo Bernardi Sara Mastaglio Silvio Bicciato Paolo Dellabona Giulia Casorati |
| author_facet |
Michela Consonni Claudio Garavaglia Andrea Grilli Claudia de Lalla Alessandra Mancino Lucia Mori Gennaro De Libero Daniela Montagna Monica Casucci Marta Serafini Chiara Bonini Daniel Häussinger Fabio Ciceri Massimo Bernardi Sara Mastaglio Silvio Bicciato Paolo Dellabona Giulia Casorati |
| author_sort |
Michela Consonni |
| title |
Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia |
| title_short |
Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia |
| title_full |
Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia |
| title_fullStr |
Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia |
| title_full_unstemmed |
Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia |
| title_sort |
human t cells engineered with a leukemia lipid-specific tcr enables donor-unrestricted recognition of cd1c-expressing leukemia |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a21e6ce293244d2e824f24fa9452ea8d |
| work_keys_str_mv |
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