Synthetic Strategy Towards Heterodimetallic Half-Sandwich Complexes Based on a Symmetric Ditopic Ligand

Multimetallic complexes have been shown in several examples to possess greater anticancer activity than their monometallic counterparts. The increased activity has been attributed to altered modes of action. We herein report the synthesis of a series of heterodimetallic compounds based on a ditopic...

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Autores principales:	Lewis P. M. Green, Tasha R. Steel, Mie Riisom, Muhammad Hanif, Tilo Söhnel, Stephen M. F. Jamieson, L. James Wright, James D. Crowley, Christian G. Hartinger
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	anticancer activity structural characterization ligand exchange reactions bioorganometallics heterodimetallic complexes Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/a21f05c5e4db47739cd389b575891a47
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spelling	oai:doaj.org-article:a21f05c5e4db47739cd389b575891a472021-12-03T04:38:15ZSynthetic Strategy Towards Heterodimetallic Half-Sandwich Complexes Based on a Symmetric Ditopic Ligand2296-264610.3389/fchem.2021.786367https://doaj.org/article/a21f05c5e4db47739cd389b575891a472021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.786367/fullhttps://doaj.org/toc/2296-2646Multimetallic complexes have been shown in several examples to possess greater anticancer activity than their monometallic counterparts. The increased activity has been attributed to altered modes of action. We herein report the synthesis of a series of heterodimetallic compounds based on a ditopic ligand featuring 2-pyridylimine chelating motifs and organometallic half-sandwich moieties. The complexes were characterized by a combination of 1H NMR spectroscopy, electrospray ionization mass spectrometry, elemental analysis and single crystal X-ray diffraction. Investigations into the stability of representative complexes in DMSO-d6 and 10% DMSO-d6/D2O revealed the occurrence of solvent-chlorido ligand exchange. Proliferation assays in four human cancer cell lines showed that the Os-Rh complex possessed minimal activity, while all other complexes were inactive.Lewis P. M. GreenTasha R. SteelMie RiisomMie RiisomMuhammad HanifTilo SöhnelStephen M. F. JamiesonL. James WrightJames D. CrowleyChristian G. HartingerFrontiers Media S.A.articleanticancer activitystructural characterizationligand exchange reactionsbioorganometallicsheterodimetallic complexesChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anticancer activity structural characterization ligand exchange reactions bioorganometallics heterodimetallic complexes Chemistry QD1-999
spellingShingle	anticancer activity structural characterization ligand exchange reactions bioorganometallics heterodimetallic complexes Chemistry QD1-999 Lewis P. M. Green Tasha R. Steel Mie Riisom Mie Riisom Muhammad Hanif Tilo Söhnel Stephen M. F. Jamieson L. James Wright James D. Crowley Christian G. Hartinger Synthetic Strategy Towards Heterodimetallic Half-Sandwich Complexes Based on a Symmetric Ditopic Ligand
description	Multimetallic complexes have been shown in several examples to possess greater anticancer activity than their monometallic counterparts. The increased activity has been attributed to altered modes of action. We herein report the synthesis of a series of heterodimetallic compounds based on a ditopic ligand featuring 2-pyridylimine chelating motifs and organometallic half-sandwich moieties. The complexes were characterized by a combination of 1H NMR spectroscopy, electrospray ionization mass spectrometry, elemental analysis and single crystal X-ray diffraction. Investigations into the stability of representative complexes in DMSO-d6 and 10% DMSO-d6/D2O revealed the occurrence of solvent-chlorido ligand exchange. Proliferation assays in four human cancer cell lines showed that the Os-Rh complex possessed minimal activity, while all other complexes were inactive.
format	article
author	Lewis P. M. Green Tasha R. Steel Mie Riisom Mie Riisom Muhammad Hanif Tilo Söhnel Stephen M. F. Jamieson L. James Wright James D. Crowley Christian G. Hartinger
author_facet	Lewis P. M. Green Tasha R. Steel Mie Riisom Mie Riisom Muhammad Hanif Tilo Söhnel Stephen M. F. Jamieson L. James Wright James D. Crowley Christian G. Hartinger
author_sort	Lewis P. M. Green
title	Synthetic Strategy Towards Heterodimetallic Half-Sandwich Complexes Based on a Symmetric Ditopic Ligand
title_short	Synthetic Strategy Towards Heterodimetallic Half-Sandwich Complexes Based on a Symmetric Ditopic Ligand
title_full	Synthetic Strategy Towards Heterodimetallic Half-Sandwich Complexes Based on a Symmetric Ditopic Ligand
title_fullStr	Synthetic Strategy Towards Heterodimetallic Half-Sandwich Complexes Based on a Symmetric Ditopic Ligand
title_full_unstemmed	Synthetic Strategy Towards Heterodimetallic Half-Sandwich Complexes Based on a Symmetric Ditopic Ligand
title_sort	synthetic strategy towards heterodimetallic half-sandwich complexes based on a symmetric ditopic ligand
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a21f05c5e4db47739cd389b575891a47
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Synthetic Strategy Towards Heterodimetallic Half-Sandwich Complexes Based on a Symmetric Ditopic Ligand

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