Ketogenic diet effects on inflammatory allodynia and ongoing pain in rodents

Abstract Ketogenic diets are very low carbohydrate, high fat, moderate protein diets used to treat medication-resistant epilepsy. Growing evidence suggests that one of the ketogenic diet’s main mechanisms of action is reducing inflammation. Here, we examined the diet’s effects on experimental inflam...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	David N. Ruskin, Isabella C. Sturdevant, Livia S. Wyss, Susan A. Masino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a2233980eb4e482faef1f28fb76f029c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a2233980eb4e482faef1f28fb76f029c
record_format	dspace
spelling	oai:doaj.org-article:a2233980eb4e482faef1f28fb76f029c2021-12-02T14:01:22ZKetogenic diet effects on inflammatory allodynia and ongoing pain in rodents10.1038/s41598-020-80727-x2045-2322https://doaj.org/article/a2233980eb4e482faef1f28fb76f029c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80727-xhttps://doaj.org/toc/2045-2322Abstract Ketogenic diets are very low carbohydrate, high fat, moderate protein diets used to treat medication-resistant epilepsy. Growing evidence suggests that one of the ketogenic diet’s main mechanisms of action is reducing inflammation. Here, we examined the diet’s effects on experimental inflammatory pain in rodent models. Young adult rats and mice were placed on the ketogenic diet or maintained on control diet. After 3–4 weeks on their respective diets, complete Freund’s adjuvant (CFA) was injected in one hindpaw to induce inflammation; the contralateral paw was used as the control. Tactile sensitivity (von Frey) and indicators of spontaneous pain were quantified before and after CFA injection. Ketogenic diet treatment significantly reduced tactile allodynia in both rats and mice, though with a species-specific time course. There was a strong trend to reduced spontaneous pain in rats but not mice. These data suggest that ketogenic diets or other ketogenic treatments might be useful treatments for conditions involving inflammatory pain.David N. RuskinIsabella C. SturdevantLivia S. WyssSusan A. MasinoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David N. Ruskin Isabella C. Sturdevant Livia S. Wyss Susan A. Masino Ketogenic diet effects on inflammatory allodynia and ongoing pain in rodents
description	Abstract Ketogenic diets are very low carbohydrate, high fat, moderate protein diets used to treat medication-resistant epilepsy. Growing evidence suggests that one of the ketogenic diet’s main mechanisms of action is reducing inflammation. Here, we examined the diet’s effects on experimental inflammatory pain in rodent models. Young adult rats and mice were placed on the ketogenic diet or maintained on control diet. After 3–4 weeks on their respective diets, complete Freund’s adjuvant (CFA) was injected in one hindpaw to induce inflammation; the contralateral paw was used as the control. Tactile sensitivity (von Frey) and indicators of spontaneous pain were quantified before and after CFA injection. Ketogenic diet treatment significantly reduced tactile allodynia in both rats and mice, though with a species-specific time course. There was a strong trend to reduced spontaneous pain in rats but not mice. These data suggest that ketogenic diets or other ketogenic treatments might be useful treatments for conditions involving inflammatory pain.
format	article
author	David N. Ruskin Isabella C. Sturdevant Livia S. Wyss Susan A. Masino
author_facet	David N. Ruskin Isabella C. Sturdevant Livia S. Wyss Susan A. Masino
author_sort	David N. Ruskin
title	Ketogenic diet effects on inflammatory allodynia and ongoing pain in rodents
title_short	Ketogenic diet effects on inflammatory allodynia and ongoing pain in rodents
title_full	Ketogenic diet effects on inflammatory allodynia and ongoing pain in rodents
title_fullStr	Ketogenic diet effects on inflammatory allodynia and ongoing pain in rodents
title_full_unstemmed	Ketogenic diet effects on inflammatory allodynia and ongoing pain in rodents
title_sort	ketogenic diet effects on inflammatory allodynia and ongoing pain in rodents
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a2233980eb4e482faef1f28fb76f029c
work_keys_str_mv	AT davidnruskin ketogenicdieteffectsoninflammatoryallodyniaandongoingpaininrodents AT isabellacsturdevant ketogenicdieteffectsoninflammatoryallodyniaandongoingpaininrodents AT liviaswyss ketogenicdieteffectsoninflammatoryallodyniaandongoingpaininrodents AT susanamasino ketogenicdieteffectsoninflammatoryallodyniaandongoingpaininrodents
_version_	1718392159604834304

Ketogenic diet effects on inflammatory allodynia and ongoing pain in rodents

Ejemplares similares