Hypersensitivity to DNA damage in antephase as a safeguard for genome stability

The DNA damage response induces a reversible arrest at different cell cycle stages. Here the authors find that loss of the APC/C inhibitor Emi1 in antephase (late G2) results in hypersensitivity to DNA damage and cell cycle exit at DNA damage levels that induce a reversible arrest in early G2.

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Autores principales:	Femke M. Feringa, Lenno Krenning, André Koch, Jeroen van den Berg, Bram van den Broek, Kees Jalink, René H. Medema
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a2284338e2d945e09762ac87bdafcf59
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spelling	oai:doaj.org-article:a2284338e2d945e09762ac87bdafcf592021-12-02T17:32:22ZHypersensitivity to DNA damage in antephase as a safeguard for genome stability10.1038/ncomms126182041-1723https://doaj.org/article/a2284338e2d945e09762ac87bdafcf592016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12618https://doaj.org/toc/2041-1723The DNA damage response induces a reversible arrest at different cell cycle stages. Here the authors find that loss of the APC/C inhibitor Emi1 in antephase (late G2) results in hypersensitivity to DNA damage and cell cycle exit at DNA damage levels that induce a reversible arrest in early G2.Femke M. FeringaLenno KrenningAndré KochJeroen van den BergBram van den BroekKees JalinkRené H. MedemaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Femke M. Feringa Lenno Krenning André Koch Jeroen van den Berg Bram van den Broek Kees Jalink René H. Medema Hypersensitivity to DNA damage in antephase as a safeguard for genome stability
description	The DNA damage response induces a reversible arrest at different cell cycle stages. Here the authors find that loss of the APC/C inhibitor Emi1 in antephase (late G2) results in hypersensitivity to DNA damage and cell cycle exit at DNA damage levels that induce a reversible arrest in early G2.
format	article
author	Femke M. Feringa Lenno Krenning André Koch Jeroen van den Berg Bram van den Broek Kees Jalink René H. Medema
author_facet	Femke M. Feringa Lenno Krenning André Koch Jeroen van den Berg Bram van den Broek Kees Jalink René H. Medema
author_sort	Femke M. Feringa
title	Hypersensitivity to DNA damage in antephase as a safeguard for genome stability
title_short	Hypersensitivity to DNA damage in antephase as a safeguard for genome stability
title_full	Hypersensitivity to DNA damage in antephase as a safeguard for genome stability
title_fullStr	Hypersensitivity to DNA damage in antephase as a safeguard for genome stability
title_full_unstemmed	Hypersensitivity to DNA damage in antephase as a safeguard for genome stability
title_sort	hypersensitivity to dna damage in antephase as a safeguard for genome stability
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a2284338e2d945e09762ac87bdafcf59
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Hypersensitivity to DNA damage in antephase as a safeguard for genome stability

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