Hypersensitivity to DNA damage in antephase as a safeguard for genome stability

The DNA damage response induces a reversible arrest at different cell cycle stages. Here the authors find that loss of the APC/C inhibitor Emi1 in antephase (late G2) results in hypersensitivity to DNA damage and cell cycle exit at DNA damage levels that induce a reversible arrest in early G2.

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Autores principales: Femke M. Feringa, Lenno Krenning, André Koch, Jeroen van den Berg, Bram van den Broek, Kees Jalink, René H. Medema
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/a2284338e2d945e09762ac87bdafcf59
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