The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins

ABSTRACT Type I interferon (IFN)-stimulated genes (ISGs) have critical roles in inhibiting virus replication and dissemination. Despite advances in understanding the molecular basis of ISG restriction, the antiviral mechanisms of many remain unclear. The 20-kDa ISG ISG20 is a nuclear 3′–5′ exonuclea...

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Autores principales: Christopher M. Weiss, Derek W. Trobaugh, Chengqun Sun, Tiffany M. Lucas, Michael S. Diamond, Kate D. Ryman, William B. Klimstra
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
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Acceso en línea:https://doaj.org/article/a2287e9b9d7344b2a42e47c800dea8d0
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