The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension

Survival and proliferation of vascular cells in the presence of DNA damage is a characteristic of pulmonary arterial hypertension. Here the authors show that the phosphatase EYA3 contributes to vascular remodeling by promoting survival of damaged cells, and present results of genetic and pharmacolog...

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Autores principales:	Yuhua Wang, Ram Naresh Pandey, Allen J. York, Jaya Mallela, William C. Nichols, Yueh-Chiang Hu, Jeffery D. Molkentin, Kathryn A. Wikenheiser-Brokamp, Rashmi S. Hegde
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a22dbf3a31634184aa871160e2f3a493
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spelling	oai:doaj.org-article:a22dbf3a31634184aa871160e2f3a4932021-12-02T14:38:47ZThe EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension10.1038/s41467-019-12226-12041-1723https://doaj.org/article/a22dbf3a31634184aa871160e2f3a4932019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12226-1https://doaj.org/toc/2041-1723Survival and proliferation of vascular cells in the presence of DNA damage is a characteristic of pulmonary arterial hypertension. Here the authors show that the phosphatase EYA3 contributes to vascular remodeling by promoting survival of damaged cells, and present results of genetic and pharmacological EYA3 inhibition.Yuhua WangRam Naresh PandeyAllen J. YorkJaya MallelaWilliam C. NicholsYueh-Chiang HuJeffery D. MolkentinKathryn A. Wikenheiser-BrokampRashmi S. HegdeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuhua Wang Ram Naresh Pandey Allen J. York Jaya Mallela William C. Nichols Yueh-Chiang Hu Jeffery D. Molkentin Kathryn A. Wikenheiser-Brokamp Rashmi S. Hegde The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension
description	Survival and proliferation of vascular cells in the presence of DNA damage is a characteristic of pulmonary arterial hypertension. Here the authors show that the phosphatase EYA3 contributes to vascular remodeling by promoting survival of damaged cells, and present results of genetic and pharmacological EYA3 inhibition.
format	article
author	Yuhua Wang Ram Naresh Pandey Allen J. York Jaya Mallela William C. Nichols Yueh-Chiang Hu Jeffery D. Molkentin Kathryn A. Wikenheiser-Brokamp Rashmi S. Hegde
author_facet	Yuhua Wang Ram Naresh Pandey Allen J. York Jaya Mallela William C. Nichols Yueh-Chiang Hu Jeffery D. Molkentin Kathryn A. Wikenheiser-Brokamp Rashmi S. Hegde
author_sort	Yuhua Wang
title	The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension
title_short	The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension
title_full	The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension
title_fullStr	The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension
title_full_unstemmed	The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension
title_sort	eya3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a22dbf3a31634184aa871160e2f3a493
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The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension

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