Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition

The tumor suppressor GATA4 is frequently epigenetically silenced in lung cancer. In this study, Gao et al. demonstrate that GATA4 regulates the expression of TGFBR2 and that TGFRB1 inhibitors can synergise with chemotherapeutics to inhibit the growth of GATA4-deficient tumors in mice.

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Autores principales:	Lei Gao, Yong Hu, Yahui Tian, Zhenzhen Fan, Kun Wang, Hongdan Li, Qian Zhou, Guandi Zeng, Xin Hu, Lei Yu, Shiyu Zhou, Xinyuan Tong, Hsinyi Huang, Haiquan Chen, Qingsong Liu, Wanting Liu, Gong Zhang, Musheng Zeng, Guangbiao Zhou, Qingyu He, Hongbin Ji, Liang Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a22e2b802e16470085f09c63c8826bf0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:a22e2b802e16470085f09c63c8826bf02021-12-02T15:36:18ZLung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition10.1038/s41467-019-09295-72041-1723https://doaj.org/article/a22e2b802e16470085f09c63c8826bf02019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09295-7https://doaj.org/toc/2041-1723The tumor suppressor GATA4 is frequently epigenetically silenced in lung cancer. In this study, Gao et al. demonstrate that GATA4 regulates the expression of TGFBR2 and that TGFRB1 inhibitors can synergise with chemotherapeutics to inhibit the growth of GATA4-deficient tumors in mice.Lei GaoYong HuYahui TianZhenzhen FanKun WangHongdan LiQian ZhouGuandi ZengXin HuLei YuShiyu ZhouXinyuan TongHsinyi HuangHaiquan ChenQingsong LiuWanting LiuGong ZhangMusheng ZengGuangbiao ZhouQingyu HeHongbin JiLiang ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Gao Yong Hu Yahui Tian Zhenzhen Fan Kun Wang Hongdan Li Qian Zhou Guandi Zeng Xin Hu Lei Yu Shiyu Zhou Xinyuan Tong Hsinyi Huang Haiquan Chen Qingsong Liu Wanting Liu Gong Zhang Musheng Zeng Guangbiao Zhou Qingyu He Hongbin Ji Liang Chen Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition
description	The tumor suppressor GATA4 is frequently epigenetically silenced in lung cancer. In this study, Gao et al. demonstrate that GATA4 regulates the expression of TGFBR2 and that TGFRB1 inhibitors can synergise with chemotherapeutics to inhibit the growth of GATA4-deficient tumors in mice.
format	article
author	Lei Gao Yong Hu Yahui Tian Zhenzhen Fan Kun Wang Hongdan Li Qian Zhou Guandi Zeng Xin Hu Lei Yu Shiyu Zhou Xinyuan Tong Hsinyi Huang Haiquan Chen Qingsong Liu Wanting Liu Gong Zhang Musheng Zeng Guangbiao Zhou Qingyu He Hongbin Ji Liang Chen
author_facet	Lei Gao Yong Hu Yahui Tian Zhenzhen Fan Kun Wang Hongdan Li Qian Zhou Guandi Zeng Xin Hu Lei Yu Shiyu Zhou Xinyuan Tong Hsinyi Huang Haiquan Chen Qingsong Liu Wanting Liu Gong Zhang Musheng Zeng Guangbiao Zhou Qingyu He Hongbin Ji Liang Chen
author_sort	Lei Gao
title	Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition
title_short	Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition
title_full	Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition
title_fullStr	Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition
title_full_unstemmed	Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition
title_sort	lung cancer deficient in the tumor suppressor gata4 is sensitive to tgfbr1 inhibition
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a22e2b802e16470085f09c63c8826bf0
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Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition

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