A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation

A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation

IKK2 is the main mediator of the NF-kappaB pathway. Here, the authors demonstrate that LMP1 sustains the survival of Epstein-Barr virus-transformed human B cells and post-transplant lymphoma through IKK2 that induces JNK signaling through TPL2.

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Autores principales: Stefanie Voigt, Kai R. Sterz, Fabian Giehler, Anne-Wiebe Mohr, Joanna B. Wilson, Andreas Moosmann, Arnd Kieser
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/a2305298494b481ca6cef8d55610d0b9
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spelling oai:doaj.org-article:a2305298494b481ca6cef8d55610d0b92021-12-02T15:34:12ZA central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation10.1038/s41467-020-14502-x2041-1723https://doaj.org/article/a2305298494b481ca6cef8d55610d0b92020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14502-xhttps://doaj.org/toc/2041-1723IKK2 is the main mediator of the NF-kappaB pathway. Here, the authors demonstrate that LMP1 sustains the survival of Epstein-Barr virus-transformed human B cells and post-transplant lymphoma through IKK2 that induces JNK signaling through TPL2.Stefanie VoigtKai R. SterzFabian GiehlerAnne-Wiebe MohrJoanna B. WilsonAndreas MoosmannArnd KieserNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Stefanie Voigt
Kai R. Sterz
Fabian Giehler
Anne-Wiebe Mohr
Joanna B. Wilson
Andreas Moosmann
Arnd Kieser
A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation
description IKK2 is the main mediator of the NF-kappaB pathway. Here, the authors demonstrate that LMP1 sustains the survival of Epstein-Barr virus-transformed human B cells and post-transplant lymphoma through IKK2 that induces JNK signaling through TPL2.
format article
author Stefanie Voigt
Kai R. Sterz
Fabian Giehler
Anne-Wiebe Mohr
Joanna B. Wilson
Andreas Moosmann
Arnd Kieser
author_facet Stefanie Voigt
Kai R. Sterz
Fabian Giehler
Anne-Wiebe Mohr
Joanna B. Wilson
Andreas Moosmann
Arnd Kieser
author_sort Stefanie Voigt
title A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation
title_short A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation
title_full A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation
title_fullStr A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation
title_full_unstemmed A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation
title_sort central role of ikk2 and tpl2 in jnk activation and viral b-cell transformation
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/a2305298494b481ca6cef8d55610d0b9
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